161596-17-4

Basic information

• Product Name: ethyl 1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate
• Synonyms: ethyl 1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate
• CAS NO: 161596-17-4
• Molecular Weight: 222.284
• Mol File: 161596-17-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ethyl 1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate(161596-17-4)
• EPA Substance Registry System: ethyl 1-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate(161596-17-4)

Safety Data

• Hazardous Substances Data: 161596-17-4(Hazardous Substances Data)

Upstream product

• 620-79-1 Ethyl 2-benzylacetoacetate 
• 100-39-0 benzyl bromide 
• 141-97-9 ethyl acetoacetate 
• 107289-11-2 (2R,5R,6R)-5-Benzyl-2-(tert-butyl)-6-methyl-1,3-dioxan-4-on 
• 64-17-5 ethanol 
• 107289-17-8 (2R,3R)-2-benzyl-3-hydroxy-butyric acid 
• 24915-95-5 Ethyl (R)-3-hydroxybutanoate 

Downstream Products

• 916750-92-0 C₁₅H₂₂O₄ 

Relevant articles and documents

Enantioselective and Diastereoselective Ir-Catalyzed Hydrogenation of α-Substituted β-Ketoesters via Dynamic Kinetic Resolution

An iridium/f-amphol catalytic system for the enantioselective hydrogenation of α-substituted β-ketoesters via dynamic kinetic resolution is reported. The desired anti products were obtained in high yields (up to 98%) with good diastereoselectivity (up to 96:4 diastereometic ratio (dr)) and excellent enantioselectivity (up to >99% enantiomeric excess (ee)). A catalytic model is proposed to explain the stereoselectivity.

A recombinant ketoreductase tool-box. Assessing the substrate selectivity and stereoselectivity toward the reduction of β-ketoesters

The substrate selectivity and stereoselectivity of a series of ketoreductases were evaluated toward the reduction of two sets of β-ketoesters. Both the structural variety at β-position and the substituent at α-position greatly affected the activity and stereoselectivity of these ketoreductases. For the first set of β-ketoesters, at least one ketoreductase was found that catalyzed the formation of either (d) or (l) enantiomer of β-hydroxyesters from each substrate with high optical purity, with the only exception of ethyl (d)-3-hydroxy-3-phenylpropionate. For the second set of β-ketoesters with α-substituents, the situation is more complex. More commonly, a ketoreductase was found that formed one of the four diastereomers in optically pure form, with only a few cases in which enzymes could be found that formed two or more of the diastereomers in high optical purity. The continued development of new, more diverse ketoreductases will create the capability to produce a wider range of single diastereomers of 2-substituted-3-hydroxy acids and their derivatives.