1616267-18-5Relevant articles and documents
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
Chen, Young K.,Bonaldi, Tiziana,Cuomo, Alessandro,Del Rosario, Joselyn R.,Hosfield, David J.,Kanouni, Toufike,Kao, Shih-Chu,Lai, Chon,Lobo, Neethan A.,Matuszkiewicz, Jennifer,McGeehan, Andrew,O'Connell, Shawn M.,Shi, Lihong,Stafford, Jeffrey A.,Stansfield, Ryan K.,Veal, James M.,Weiss, Michael S.,Yuen, Natalie Y.,Wallace, Michael B.
, p. 869 - 874 (2017/08/16)
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulat