161832-71-9

Basic information

• Product Name: (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide
• Synonyms: 7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide, 5-(4-aminophenyl)-8,9-dihydro-N,8-dimethyl-, (8R)-
• CAS NO: 161832-71-9
• Molecular Formula: C₁₉H₂₀N₄O₃
• Molecular Weight: 352.3871
• Mol File: 161832-71-9.mol
• Article Data: 6

Chemical Properties

• Density: 1.41g/cm³
• Refractive Index: 1.686
• CAS DataBase Reference: (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide(161832-71-9)
• EPA Substance Registry System: (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide(161832-71-9)

Safety Data

• Hazardous Substances Data: 161832-71-9(Hazardous Substances Data)

Usage

Description

(8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide is a complex organic compound characterized by a benzodiazepine backbone. It features an amine group, a phenyl group, and a carboxamide functional group, along with a dioxolo ring system. This molecule is likely to possess pharmacological properties, potentially influencing the central nervous system. Further research and testing are required to ascertain its specific activity and potential applications.

Uses

Used in Pharmaceutical Industry:
(8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide is used as a potential therapeutic agent for [application reason] due to its complex structure and pharmacological properties that may act on the central nervous system.
Used in Research and Development:
In the field of chemical research and development, (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide serves as a subject for further investigation to determine its specific activity, potential uses, and mechanisms of action.

Upstream product

• 143692-49-3 1-(4-Nitrophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine 
• 624-83-9 methyl isocyanate 

Relevant articles and documents

N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) R stands for a C1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C1-4 alkylamino, di(C1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group, or by one or more halogen(s); or R is a benzoyl, cyclopropanecarbonyl, C1-5 alkylcarbamoyl or phenylcarbamoyl group; or R is absent when a double bond exists between the N(3) and C(4) atoms; R1 means hydrogen; or R1 is absent when a double bond exists between the N(3) and C(4) atoms; R2 means a C1-3 alkyl group; or R1 and R2 together stand for a methylene group and no double bond is present between the N(3) and C(4) atoms; R3 means hydrogen or a C1-4 alkanoyl group; R4 represents hydrogen; a C1-6 alkanoyl group optionally substituted by a methoxy, cyano, carboxyl, amino, C1-4 alkylamino, di(C1-4 alkyl)amino, pyrrolidino, phthalimido or phenyl group or by one or more halogen(s); as well as a benzoyl, palmitoyl, cyclopropanecarbonyl, C1-5 alkylcarbamoyl or phenylcarbamoyl group; and the dotted lines represent valence bonds optionally being present, with the proviso that no double bond exists between the N(3) and C(4) atoms when both R3 and R4 stand for hydrogen. The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.

N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives and a method of treating spasms of the skeletal musculature therewith.

N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same

The invention relates to novel N-acyl-2,3-benzodiezapine derivatives of the general formula (I), their stereoisomers and acid-addition salts, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I), defined in the specification, a more complete description of the compounds may be found.The compounds of the general formula (I) possess valuable central nervous system effects, particularly muscle-relaxant, anticonvulsive and neuroprotective action. Thus, they may be useful for the treatment of various diseases of central nervous system origin.