161886-18-6 Usage
Physical state
Colorless solid The compound appears as a colorless solid at room temperature.
Solubility
Insoluble in water, sparingly soluble in organic solvents The compound does not dissolve well in water and only dissolves to a small extent in organic solvents.
Uses
Building block in the synthesis of pharmaceuticals and agrochemicals 2,2-difluoro-1,3-benzodioxol-4-carbonitrile is used as a starting material to create various drugs and chemicals used in agriculture.
Uses
Intermediate in the production of fine chemicals The compound serves as an intermediate in the manufacturing process of specialized or high-quality chemicals.
Chemical reactivity
Unique structure with fluorine and nitrile groups The presence of both fluorine and nitrile groups in the compound's structure results in a range of chemical reactivity, making it useful in various organic synthesis applications.
Handling precautions
Potentially hazardous if not used properly Due to its unique chemical properties, it is important to handle 2,2-difluoro-1,3-benzodioxol-4-carbonitrile with care to avoid any hazardous situations.
Check Digit Verification of cas no
The CAS Registry Mumber 161886-18-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,8,8 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 161886-18:
(8*1)+(7*6)+(6*1)+(5*8)+(4*8)+(3*6)+(2*1)+(1*8)=156
156 % 10 = 6
So 161886-18-6 is a valid CAS Registry Number.
161886-18-6Relevant articles and documents
A homologous series of O- and N-functionalized 2,2-difluoro-1,3-benzodioxoles: An exercise in organometallic methodology
Schlosser, Manfred,Gorecka, Joanna,Castagnetti, Eva
, p. 452 - 462 (2007/10/03)
The conversion of 2,2-difluoro-1,3-benzodioxole, an exceptionally acidic arene, via a 4-lithiated intermediate into more than three dozen new derivatives was conceived as a case study. The lithiated species was trapped by C0-electrophiles (4-toluenesulfonyl azide, fluorodimethoxyborane, iodine), C1-electrophiles (carbon dioxide, N,N-dimethylformamide, formaldehyde, dimethyl sulfate), C2-electrophiles (oxalic acid diesters, oxirane), C3-electrophiles (oxetane), and higher alkyl iodides. The resulting carboxylic acid 1a may be treated with organolithium compounds to afford ketones (e.g. 10) and the aldehyde 9 can be condensed with nitromethane or acetic anhydride under basic conditions. If not oxidized with chromium trioxide to the corresponding carboxylic acids, the alcohols 2b, 2c, and 2d can be transformed into the corresponding bromides (12) or sulfonates (13). Their condensation with nitrogen-containing C0-nucleophiles (hydroxylamine, sodium azide, potassium phthalimide), C1-nucleophiles (potassium cyanide), and C2-nucleophiles (aceto-nitrile) opens a convenient access to the amines 3. Other reactions gave, despite a proven track record in other areas, only moderate yields. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
