1619261-38-9

Basic information

• Product Name: (R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate
• Synonyms: (R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate
• CAS NO: 1619261-38-9
• Molecular Weight: 295.379
• Mol File: 1619261-38-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate(1619261-38-9)
• EPA Substance Registry System: (R)-tert-butyl 4-hydroxy-1-(3-methoxy-phenyl)butan-2-ylcarbamate(1619261-38-9)

Safety Data

• Hazardous Substances Data: 1619261-38-9(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 128427-10-1 (S)-2-(tert-butoxycarbonylamino)-1,4-butanediol 
• 1619261-25-4 (R)-3-(tert-butoxycarbonylamino)-4-(3-methoxyphenyl)butyl 4-methylbenzenesulfonate 
• 1619261-23-2 (S)-tert-butyl-(2-(2-tosyloxy)ethyl)aziridine-1-carboxylate 

Downstream Products

• 1619261-39-0 (R)-3-amino-4-(3-methoxyphenyl)butan-1-ol hydrochloride 
• 1619261-42-5 (R)-2-(4-hydroxy-1-(3-methoxyphenyl)-butan-2-yl)isoindoline-1,3-dione 

Relevant articles and documents

Synthesis of (S)-2-amino-7-methoxytetralin and isoindolo[1,2-a]isoquinolinone derivatives from l-aspartic acid

This paper describes a new total synthesis for (S)-2-amino-7-methoxytetralin, (S)-7-MeO-AT, from l-aspartic acid in an overall yield of 10% over nine steps. The major loss was ascribed to a key intramolecular Friedel-Crafts cyclization step, which afforded up to 36% yield. Attempts to perform a Friedel-Crafts cyclization of an intermediate phthalimide protected amino alcohol 13 did not give the desired protected (S)-7-MeO-AT. On the other hand, two new isoindolo[1,2-a]isoquinolinone derivatives 14 and 15, were isolated in 21 and 11% yield, respectively. The yield of 15 was improved to 70%.