1620024-67-0

Basic information

• Product Name: N₂-((6-chloropyridin-3-yl)methyl)-N₂,N₆,1-trimethyl-3,5-dinitro-4-phenyl-1,4-dihydropyridine-2,6-diamine
• Synonyms: N₂-((6-chloropyridin-3-yl)methyl)-N₂,N₆,1-trimethyl-3,5-dinitro-4-phenyl-1,4-dihydropyridine-2,6-diamine
• CAS NO: 1620024-67-0
• Molecular Weight: 444.878
• Mol File: 1620024-67-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N₂-((6-chloropyridin-3-yl)methyl)-N₂,N₆,1-trimethyl-3,5-dinitro-4-phenyl-1,4-dihydropyridine-2,6-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N₂-((6-chloropyridin-3-yl)methyl)-N₂,N₆,1-trimethyl-3,5-dinitro-4-phenyl-1,4-dihydropyridine-2,6-diamine(1620024-67-0)
• EPA Substance Registry System: N₂-((6-chloropyridin-3-yl)methyl)-N₂,N₆,1-trimethyl-3,5-dinitro-4-phenyl-1,4-dihydropyridine-2,6-diamine(1620024-67-0)

Safety Data

• Hazardous Substances Data: 1620024-67-0(Hazardous Substances Data)

Upstream product

• 1620024-38-5 N,1-dimethyl-6-(methylthio)-3,5-dinitro-4-phenyl-1,4-dihydropyridin-2-amine 
• 120739-62-0 1-(6-chloropyridin-3-yl)-N-methylmethanamine 
• 100-52-7 benzaldehyde 

Relevant articles and documents

One-pot pseudo three-component reaction of nitroketene-N,S-acetals and aldehydes for synthesis of highly functionalized hexa-substituted 1,4-dihydropyridines

We have described the simple, convenient and high yielding one-pot synthesis of a library of highly functionalized hexa-substituted 1,4-dihydropyridines (1,4-DHPs) by 2-aminopyridine catalysed pseudo three-component reaction of nitroketene-N,S-acetals and aldehydes. This domino transformation involves formation of dihydropyridine ring by creation of two C-C bonds and one C-N bond, all of them taking place in a single synthetic operation. As the products precipitate out of the reaction simple filtration is enough to gather the products and thus, there is no need for work-up or column-chromatography. The C6-methylsulfanyl group in the product 1,4-DHPs was substituted with primary and secondary amines to provide 1,4-DHPs with further possibilities in structural diversity. As a demonstration of application of the method we have synthesised an analogue of nitenpyram, a neonicotinoid insecticide. This journal is the Partner Organisations 2014.