1620097-06-4Relevant articles and documents
Biocatalytic Access to 1,4-Diazepanes via Imine Reductase-Catalyzed Intramolecular Asymmetric Reductive Amination
Feng, Jinhui,Li, Jianjiong,Li, Jinlong,Sheng, Xiang,Wu, Qiaqing,Xu, Zefei,Yao, Peiyuan,Yu, Shanshan,Zhu, Dunming
, p. 8780 - 8787 (2020)
An enzymatic intramolecular asymmetric reductive amination has been developed for the synthesis of chiral 1,4-diazepanes. Several enantiocomplementary IREDs were identified for the synthesis of (R)-and (S)-5-chloro-2-(5-methyl-1,4-diazepan-1-yl)benzo[d]ox
PROCESS FOR THE PREPARATION OF SUVOREXANT AND INTERMEDIATES USEFUL IN THE SYNTHESIS OF SUVOREXANT
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Paragraph 0126-0127, (2016/07/05)
A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)
Facile synthesis of suvorexant, an orexin receptor antagonist, via a chiral diazepane intermediate
Chen, Yin,Zhou, Yan,Li, Jun-Hong,Sun, Jia-Quan,Zhang, Gui-Sen
, p. 103 - 107 (2015/01/30)
A facile synthesis of suvorexant, an orexin receptor antagonist, is described. The key intermediate 6 was prepared from R-3-aminobutyric acid through protection, condensation, deprotection, cyclization, and hydrogenation steps. The title product was obtained with a total yield of 31% (>99% ee) after eight linear steps using commercially available raw materials.