1620158-84-0

Basic information

• Product Name: C₈H₃⁽²⁾HF₄O₂
• Synonyms: C₈H₃⁽²⁾HF₄O₂
• CAS NO: 1620158-84-0
• Molecular Weight: 209.104
• Mol File: 1620158-84-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₈H₃⁽²⁾HF₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₃⁽²⁾HF₄O₂(1620158-84-0)
• EPA Substance Registry System: C₈H₃⁽²⁾HF₄O₂(1620158-84-0)

Safety Data

• Hazardous Substances Data: 1620158-84-0(Hazardous Substances Data)

Upstream product

• 4472-41-7 d₇-N,N-dimethylformamide 
• 1077-01-6 meta-fluoro(trifluoromethoxy)benzene 

Relevant articles and documents

Efficient synthesis of 2H & 13C labeled benzaldehydes via regio-selective formylation

Benzaldehydes are important building blocks in synthetic organic chemistry that have wide applications for the synthesis of natural products and pharmaceutical drugs. Herein we report a general synthetic methodology for the synthesis of highly functionalized 2H and 13C labeled benzaldehydes in transfer of isotopic purity >99% via regio-selective formylation. Regio-selective deprotonation of substituted benzene 1 with LDA/n-BuLi at -78 °C and treatment with DMF-d7 or EtO- 13CHO led to the synthesis of 2-deutero-1,3-disubstituted benzaldehydes 2/4 in moderate to good yields. The synthetic methodology described represents a simple yet versatile route to functionalized formyl-deuterated, tritiated 13C and 14C labeled benzaldehydes.