1620328-11-1

Basic information

• Product Name: C₂₀H₁₇F₃N₄O₂
• CAS NO: 1620328-11-1
• Molecular Weight: 402.376
• Mol File: 1620328-11-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇F₃N₄O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇F₃N₄O₂(1620328-11-1)
• EPA Substance Registry System: C₂₀H₁₇F₃N₄O₂(1620328-11-1)

Safety Data

• Hazardous Substances Data: 1620328-11-1(Hazardous Substances Data)

Upstream product

• 1160502-30-6 4-iodo-3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 1160502-29-3 2,2,2-trifluoro-1-(2-fluoro-4-iodopyridin-3-yl)ethanone 
• 1620328-07-5 C₂₀H₁₇F₃N₄O₂ 
• 1629023-87-5 C₄₂H₃₅F₃N₄O₂ 
• 1629023-82-0 C₁₆H₁₈BrNO₂ 
• 1629023-48-8 C₁₃H₁₄BrNO₂ 
• 1160502-28-2 2,2,2-trifluoro-1-(2-fluoro-4-iodopyridin-3-yl)ethanol 
• 1620327-73-2 C₁₃H₁₂BrN 
• 188347-48-0 2-(3,5-dibromophenyl)acetonitrile 
• 153034-82-3 [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde 
• 1435-51-4 1,3-dibromo-5-fluorobenzene 
• 1620327-60-7 C₃₂H₂₉BF₃N₃O₂ 
• 1160502-31-7 4-iodo-3-(trifluoromethyl)-1-tritylpyrazolo[5,4-b]pyridine 

Relevant articles and documents

Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors

Extensive phase II metabolism of an advanced PKCε inhibitor resulted in sub-optimal pharmacokinetics in rat marked by elevated clearance. Synthesis of the O-glucuronide metabolite as a standard was followed by three distinct strategies to specifically temper phase II metabolic degradation of the parent molecule. In this study, it was determined that the introduction of proximal polarity to the primary alcohol generally curbed O-glucuronidation and improved PK and physical chemical properties while maintaining potency against the target. Utilization of a Jacobsen hydrolytic kinetic resolution to obtain optically enriched final compounds is also discussed.