1621066-21-4 Usage
Description
(S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is a chiral binaphthol derivative characterized by its symmetrical structure with a binaphthalene backbone and two bulky trifluoromethylphenyl groups attached to the hydroxyl groups at the 3 and 3' positions. (S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is renowned for its role as a chiral ligand in metal-catalyzed reactions, which is particularly significant in the formation of carbon-carbon and carbon-heteroatom bonds with high enantioselectivity. Its unique structural and steric properties render it an indispensable tool in the development of novel synthetic methodologies and the production of enantioenriched compounds for various applications in pharmaceuticals, agrochemicals, and materials science.
Uses
Used in Pharmaceutical Industry:
(S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is used as a chiral ligand for [application type] in the pharmaceutical industry for [application reason] the creation of enantioenriched compounds, which are crucial in the development of new drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is utilized as a chiral ligand for [application type] the synthesis of enantioselective agrochemicals, which can enhance the effectiveness of pesticides and reduce their environmental impact.
Used in Materials Science:
(S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is employed as a chiral ligand for [application type] the development of advanced materials with specific properties in materials science, such as optically active polymers and other specialty materials with unique characteristics.
Used in Organic Synthesis:
(S)-3,3'-bis(4-(trifluoromethyl)phenyl)[1,1'-binaphthalene]-2,2'-diol is also used as a key intermediate for [application type] organic synthesis, where it aids in the creation of complex molecular structures with high enantiomeric purity, which are essential in various chemical and pharmaceutical applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1621066-21-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,1,0,6 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1621066-21:
(9*1)+(8*6)+(7*2)+(6*1)+(5*0)+(4*6)+(3*6)+(2*2)+(1*1)=124
124 % 10 = 4
So 1621066-21-4 is a valid CAS Registry Number.
1621066-21-4Relevant articles and documents
An unprecedented rhodium-catalyzed asymmetric intermolecular hydroacylation reaction with salicylaldehydes
Stemmler, Rene T.,Bolm, Carsten
, p. 1185 - 1198 (2007)
An unprecedented enantio- and diastereo-selective rhodium-catalyzed intermolecular hydroacylation reaction of salicylaldehydes with norbornenes is reported in which the corresponding aryl ketones are obtained in high diastereomeric and moderate enantiomer
Efficient synthesis of 3,3'-diaryl binaphthol through a one-step method
-
Paragraph 0048-0050, (2018/07/30)
The invention relates to a class of catalysis reactions of binaphthol and halogenated aromatic hydrocarbons, particularly to efficient preparation of 3,3'-diaryl binaphthol and 3-Bulkyaryl binaphtholthrough a one-step method, and belongs to the technical field of asymmetric catalysis. A purpose of the present invention is to provide a simple and practical method for preparing 3,3'-diaryl binaphthol through a one-step reaction of inexpensive BINOL and a brominated aromatic hydrocarbon reagent, and is further to provide a simple and rapid method for conveniently preparing 3-aryl binaphthol withhigh steric hindrance.
Ligand-accelerated stereoretentive Suzuki-Miyaura coupling of unprotected 3,3′-dibromo-BINOL
Qu, Bo,Haddad, Nizar,Rodriguez, Sonia,Sieber, Joshua D.,Desrosiers, Jean-Nicolas,Patel, Nitinchandra D.,Zhang, Yongda,Grinberg, Nelu,Lee, Heewon,Ma, Shengli,Ries, Uwe J?rg,Yee, Nathan K.,Senanayake, Chris H.
, p. 745 - 750 (2016/02/18)
An efficient synthesis of the enantiomerically pure 3,3′-bis-arylated BINOL derivatives is accomplished through the palladium-catalyzed Suzuki-Miyaura coupling of the unprotected 3,3′-dibromo-BINOL with complete retention of enantiopurity. The active cata
