16213-85-7

Basic information

• Product Name: 2,5-Dimethylphenylacetonitrile
• Synonyms: (2,5-xylyl)-acetonitril;(2,5-xylyl)acetonitrile;2,5-dimethylbenzeneacetonitrile;2,5-dimethylbenzylcyanide;2,5-Xylylacetonitrile;Acetonitrile, (2,5-xylyl)-;Benzeneacetonitrile, 2,5-dimethyl-;2,5-DIMETHYLPHENYLACETONITRILE
• CAS NO: 16213-85-7
• Molecular Formula: C₁₀H₁₁N
• Molecular Weight: 145.2
• EINECS: 240-339-3
• Product Categories: Aromatic Nitriles
• Mol File: 16213-85-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 27-29 °C
• Boiling Point: 73°C 1mm
• Flash Point: 73°C/1mm
• Appearance: /
• Density: 1.0353 (rough estimate)
• Vapor Pressure: 0.015mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• BRN: 2084136
• CAS DataBase Reference: 2,5-Dimethylphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dimethylphenylacetonitrile(16213-85-7)
• EPA Substance Registry System: 2,5-Dimethylphenylacetonitrile(16213-85-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 37/39-26-36/37
• RIDADR: 3276
• RTECS: AM2675000
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 16213-85-7(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

InChI:InChI=1/C10H11N/c1-8-3-4-9(2)10(7-8)5-6-11/h3-4,7H,5H2,1-2H3

Upstream product

• 773837-37-9 sodium cyanide 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 106-42-3 para-xylene 
• 610-72-0 2,5-dimethylbenzoic acid 
• 53957-33-8 2,5-dimethylbenzyl alcohol 
• 553-94-6 4-bromo-m-xylene 
• 75-05-8 acetonitrile 
• 95-72-7 2-chloro-1,4-dimethyl-benzene 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 

Downstream Products

• 884738-23-2 4,4,4-trifluoro-2-(2,5-dimethylphenyl)-3-oxo-butyronitrile 
• 1421922-26-0 2-(4-amino-2,5-dimethylbenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide 
• 1421922-25-9 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide 
• 1421922-24-8 2-(4-amino-2,5-dimethylbenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide 
• 1421922-23-7 2-(2,5-dimethyl-4-nitrobenzyl)-N-methyl-4-(4-methylphenyl)-1,3-thiazole-5-carboxamide 
• 1421922-22-6 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxylic acid 
• 1421922-21-5 methyl 2-(4-amino-2,5-dimethylbenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxylate 
• 1421922-20-4 methyl 2-(2,5-dimethyl-4-nitrobenzyl)-4-(4-methylphenyl)-1,3-thiazole-5-carboxylate 
• 1421922-19-1 methyl 2-(4-amino-2,5-dimethylbenzyl)-4-(4-chlorophenyl)-1,3-thiazole-5-carboxylate 
• 1421922-18-0 methyl 4-(4-chlorophenyl)-2-(2,5-dimethyl-4-nitrobenzyl)-1,3-thiazole-5-carboxylate 
• 1421922-16-8 2,5-dimethyl-4-({4-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)pyrazin-2-yl]-1,3-thiazol-2-yl}methyl)aniline 
• 1421922-15-7 2-[2-(2,5-dimethyl-4-nitrobenzyl)-1,3-thiazol-4-yl]-5-(1,1,1-trifluoro-2-methylpropan-2-yl)pyrazine 
• 1421932-36-6 4-[2-(2,5-dimethyl-4-{[(E)-(methylamino)methylidene]amino}benzyl)-1,3-thiazol-4-yl]-N-methylbenzamide 
• 1421921-88-1 methyl 2-{2-[4-({(E)-[ethyl(methyl)amino]methylidene}amino)-2,5-dimethylbenzyl]-1,3-thiazol-4-yl}-5-methylbenzoate 

Relevant articles and documents

Method for preparing 2, 5-dimethylphenylacetyl chloride

The invention discloses a method for preparing 2, 5-dimethylphenylacetyl chloride, and belongs to the field of pesticide intermediate synthesis. According to the method, p-xylene is used as an initialraw material, chloromethylation, cyaniding, hydrolysis and acylating chlorination are carried out, 2, 5-dimethylphenylacetyl chloride is obtained after continuous reaction without purification, the total yield of the four steps of reaction is 75%, and the product purity is greater than 99.0%. The method is simple in process and only needs to purify the final product and is low in operation cost,mild in reaction condition and high in yield and product purity and is very easy to realize industrial production.

Photocyclization of -(o-Tolyl)acetophenones: Triplet and 1,5-biradical reactivity

Several ring-substituted α-(o-tolyl)acetophenones undergo photocyclization to 2-indanol derivatives in high quantum efficiency in solution and in high chemical yield as solids. The mechanism for reaction involves triplet state δ-hydrogen atom abstraction that generates 1,5-biradicals. Quenching studies indicate that the n.π* excited triplets of these ketones react, with rate constants >108 s-1. Variations in triplet reactivity are ascribed to conformational equilibria that populate reactive and unreactive geometries to different extents. The α-aryl ring eclipses the carbonyl in the lowest energy geometry, from which the most favorable geometry for reaction can be reached by small bond rotations. α-(2,4,6-Triisopropylpheny)acetophenone forms the relatively long lived enol as well as indanol in solvent-dependent ratios; deuterium labeling indicates that the 1,5-biradical disproportionates to form enol. This does not happen with α-mesitylacetophenone, so its 54% cyclization quantum efficiency is ascribed to an internal triplet quenching that competes with hydrogen abstraction. This internal quenching is presumed to be of the charge-transfer type and does not appear to lead directly to 1,5-biradicals. 1-Methyl-2-phenyl-2-indanol is formed from α-(o-ethylpheny)acetophenone with a Z/E ratio of 20:1 in benzene and 2:1 in methanol. The 1,5-biradical intermediates were characterized by flash spectroscopy; they have lifetimes between 15 and 45 ns, with those derived from α-(o-isopropylphenyl) ketones being twice as long-lived as those derived from α-(o-methylphenyl) ketones, and show only a small solvent dependence. Biradical lifetimes and the diastereoselectivity of cyclization are interpreted in terms of biradical intersystem crossing occurring preferentially along the reaction coordinate for cyclization, such that the two processes effectively occur concurrently. The applicability of this concept to other biradicals is discussed.

Reaction of Various Nucleophiles with 2-Bromo-p-xylene and 4-Bromoveratrole via Aryne Reaction

-