162184-60-3Relevant articles and documents
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: Potential application for the treatment of irritable bowel syndrome
Mitch, Charles H.,Brown, Thomas J.,Bymaster, Frank P.,Calligaro, David O.,Dieckman, Donna,Merrit, Leander,Peters, Steven C.,Quimby, Steven J.,Shannon, Harlan E.,Shipley, Lisa A.,Ward, John S.,Hansen, Kristian,Olesen, Preben H.,Sauerberg, Per,Sheardown, Malcolm J.,Swedberg, Michael D. B.,Suzdak, Peter,Greenwood, Beverley
, p. 538 - 546 (1997)
Irritable bowel syndrome (IBS) is a pathophysiolocal condition characterized by abnormal bowel habits that are frequently accompanied by abdominal pain. Current therapy based on reducing high-amplitude GI contractions with nonselective muscarinic antagoni