1622304-12-4Relevant articles and documents
Method for total synthesizing α-pyrone derivatives using by gold catalyst and α-pyrone derivatives having cytotoxicity against human cancer cell synthesized thereby
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, (2017/01/31)
The present invention relates to a method for total synthesis of an andalpha;-pyrone derivative comprises preparing a andbeta;-ketoester compound starting from butanol through the Witting olefin reaction, Swern oxidation reaction, Corey-Fuchs reaction and Claisen condensation, and subjecting the andbeta;-ketoester compound to 6-endo-dig intramolecular cyclization using a gold catalyst to form an andalpha;-pyrone ring and to carry out total synthesis of an andalpha;-pyrone derivative. The andalpha;-pyrone derivative obtained by the total synthesis method is (+)-violapyrone C having the same shape as the naturally occurring andalpha;-pyrone derivative and has cytotoxicity against at least 10 human cancer cell lines, and thus can be useful as an anti-cancer agent.(AA) Tautomer(BB) Bis(trifluoromethanesulfonyl)-imidate-(triphenylphosphine)gold(I)COPYRIGHT KIPO 2016