1622905-82-1

Basic information

• Product Name: C₂₃H₂₇N₅O₅S
• CAS NO: 1622905-82-1
• Molecular Weight: 485.564
• Mol File: 1622905-82-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₇N₅O₅S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₇N₅O₅S(1622905-82-1)
• EPA Substance Registry System: C₂₃H₂₇N₅O₅S(1622905-82-1)

Safety Data

• Hazardous Substances Data: 1622905-82-1(Hazardous Substances Data)

Upstream product

• 3144-09-0 methanesulfonamide 
• 1173900-33-8 AZD 6482 

Relevant articles and documents

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine- 7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents

Optimization of AZD6482 (2), the first antiplatelet PI3Kβ inhibitor evaluated in man, focused on improving the pharmacokinetic profile to a level compatible with once daily oral dosing as well as achieving adequate selectivity towards PI3Kα to minimize the risk for insulin resistance. Structure-based design and optimization of DMPK properties resulted in (R)-16, a novel, orally bioavailable PI3Kβ inhibitor with potent in vivo anti-thrombotic effect with excellent separation to bleeding risk and insulin resistance.