1623-92-3

Basic information

• Product Name: 4-PHENOXYBENZENESULFONYL CHLORIDE
• Synonyms: BENZENESULFONYL CHLORIDE, 4-PHENOXY-;BUTTPARK 83\07-11;4-PHENOXYBENZENESULFONYL CHLORIDE;4-PHENOXYBENZENESULPHONYL CHLORIDE;4-Chlorosulphonyldiphenyl ether;4-Chlorosulfonyldiphenylether;4-Phenoxybenzenesulfonyl chloride, 98+%;4-Phenoxybenzene-1-sulfonyl chloride
• CAS NO: 1623-92-3
• Molecular Formula: C₁₂H₉ClO₃S
• Molecular Weight: 268.72
• EINECS: -0
• Product Categories: Chemical Synthesis;New Products for Chemical Synthesis;Organic Building BlocksOrganic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 1623-92-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 43-44°C
• Boiling Point: 180°C 5mm
• Flash Point: 180°C/5mm
• Appearance: /
• Density: 1.366 g/cm³
• Vapor Pressure: 3.56E-09mmHg at 25°C
• Refractive Index: 1.548
• Sensitive: Moisture Sensitive
• BRN: 2852659
• CAS DataBase Reference: 4-PHENOXYBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENOXYBENZENESULFONYL CHLORIDE(1623-92-3)
• EPA Substance Registry System: 4-PHENOXYBENZENESULFONYL CHLORIDE(1623-92-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1623-92-3(Hazardous Substances Data)

Usage

General Description

4-Phenoxybenzenesulfonyl chloride is a chemical compound with the molecular formula C12H9ClO3S. It is used in the pharmaceutical industry as a reagent for the synthesis of various organic compounds. It is a white solid that is soluble in organic solvents and reacts violently with water and strong bases. 4-PHENOXYBENZENESULFONYL CHLORIDE is an important intermediate in the manufacture of pharmaceuticals and agrochemicals, serving as a key building block for the production of sulfonamide derivatives, which are widely used as antibacterial agents and in the treatment of various medical conditions. It is also used in research and development for the synthesis of novel compounds with potential pharmaceutical applications. Additionally, it is a valuable tool in chemical synthesis for the formation of carbon-carbon and carbon-heteroatom bonds.

Upstream product

• 20241-57-0 para-phenoxybenzenesulfonic acid 
• 79-37-8 oxalyl dichloride 
• 101-84-8 diphenylether 
• 83863-63-2 2-Dibenzofuransulfonic acid 
• 101-55-3 4-Bromodiphenyl ether 

Downstream Products

• 186529-58-8 (Z)-7-[(1S,2R,3R,4R)-3-(4-Phenoxy-benzenesulfonylamino)-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester 
• 478945-53-8 N-isobutyl-N-(2-oxo-tetrahydro-thiophen-3-yl)-4-phenoxy-benzenesulfonamide 
• 607707-88-0 (2R,4'S,4S,5'R)-(4-phenoxybenzenesulfonylamino)-(2',2',2,2-tetramethyl-[4',4]bis[[1,3]dioxolanyl]-5'-yl)-acetic acid methyl ester 
• 642089-89-2 (2R,4'S,4R,5R)-(4-phenoxybenzenesulfonylamino)-[2',2',2,2-tetramethyl-[4',4]bi([1,3]dioxolanyl)-5'-yl]acetic acid methyl ester 
• 642089-92-7 (3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-phenoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid methyl ester 
• 642089-90-5 (1R,2R,4'R,5'S)-[5'-(1,2-dihydroxyethyl)-2,2'-dimethyl-[1,3]dioxolan-4'-yl]-(4-phenoxybenzenesulfonylamino)acetic acid methyl ester 
• 642089-91-6 (1S,2R,4'R,5'S)-[5'-(1-hydroxy-2-methanesulfonyloxyethyl)-2',2'-dimethyl[1,3]dioxolan-4'-yl]-(4-phenoxybenzenesulfonylamino)acetic acid methyl ester 
• 642089-94-9 (2R,3R,4R,5R)-3,4,5-trihydroxy-1-(4'-phenoxybenzenesulfonyl)-piperidine-2-carboxylic acid benzyloxyamide 
• 642089-93-8 (3aR,4R,7R,7aR)-7-hydroxy-2,2-dimethyl-5-(4'-phenoxybenzenesulfonyl)hexahydro[1,3]dioxolo[4,5-c]-4-carboxylic acid benzyloxyamide 
• 204072-55-9 Methyl-1N-(4-phenoxyphenyl)sulfonyl-4R-hydroxy-pyrrolidine-2R-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity

On the basis of the strategy of “multifunctional drugs”, a series of novel matrix metalloproteinase inhibitors (MMPIs) containing benzofuroxan scaffold as a nitric oxide donor were designed, synthesized and evaluated. All synthesized compounds, especially 16a, exhibited potent MMP-2,9 inhibitory activities, anti-proliferative activities and could produce high levels of NO in Hela cells. They were also evaluated for both of their anti-invasion and anti-angiogenesis effects. Furthermore, compared with LY52, 16a demonstrated competitive antitumor activity in vivo. These hybrid NO-MMPIs might offer suitable scaffolds to develop valuable MMP inhibitors for the further discovery of novel anti-cancer drugs.

SMALL MOLECULE INHIBITORS OF STAT3 WITH ANTI-TUMOR ACTIVITY

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Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.