1623774-99-1

Basic information

• Product Name: N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide
• Synonyms: N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide
• CAS NO: 1623774-99-1
• Molecular Weight: 334.421
• Mol File: 1623774-99-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide(1623774-99-1)
• EPA Substance Registry System: N-(2-(1-benzyl-1H-1, 2, 3-triazol-4-yl)propan-2-yl)-2-methylbenzamide(1623774-99-1)

Safety Data

• Hazardous Substances Data: 1623774-99-1(Hazardous Substances Data)

Upstream product

• 1623775-05-2 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)benzamide 
• 75-16-1 methylmagnesium bromide 
• 118-90-1 ortho-methylbenzoic acid 
• 1310826-33-5 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine 
• 933-88-0 ortho-toluoyl chloride 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 74-88-4 methyl iodide 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 622-79-7 benzyl azide 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1436849-34-1 3-methyl-N-(quinolin-8-yl)-[1,1′-biphenyl]-2-carboxamide 
• 1623775-17-6 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-4'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide 
• 1623775-03-0 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-N,2-dimethylbenzamide 
• 1623775-18-7 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3-methyl-[1,1'-biphenyl]-2-carboxamide 
• 1623775-22-3 N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-3,4'-dimethyl-[1,1'-biphenyl]-2-carboxamide 
• 1623775-23-4 N-(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)-4'-fluoro-3-methyl-[1,1'-biphenyl]-2-carboxamide 
• 1623775-24-5 N-(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)-3'-methoxy-3-methyl-[1,1'-biphenyl]-2-carboxamide 
• 1646183-95-0 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-methyl-[1,1’-biphenyl]-4-carboxylate 
• 1646184-21-5 N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3,3’-dimethyl-[1,1’-biphenyl]-2-carboxamide 
• 1646184-22-6 N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-2-methyl-6-(naphthalene-1-yl)benzamide 
• 1646184-23-7 2’-acetyl-N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-methyl-[1,1’-biphenyl]-2-carboxamide 
• 1646184-24-8 N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-2-methyl-6-(thiophen-2-yl)benzamide 
• 118-90-1 ortho-methylbenzoic acid 

Relevant articles and documents

MnCl2-Catalyzed C?H Alkylations with Alkyl Halides

C?H alkylations with challenging β-hydrogen-containing alkyl halides were accomplished with sustainable MnCl2 as the catalyst under phosphine-ligand-free conditions. The proximity-induced benzamide C?H activation occurred with ample substrate s

Expedient Iron-Catalyzed C-H Allylation/Alkylation by Triazole Assistance with Ample Scope

Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions. One for all: A unified strategy for iron-catalyzed C-H allylation and alkylation was developed by the use of a triazole directing group that could be cleaved under exceedingly mild conditions.

Iron-catalyzed C(sp2)-H and C(sp3)-H arylation by triazole assistance

Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.