1623791-69-4

Basic information

• Product Name: Carboxy-PEG4-phosphonic acid
• Synonyms: Carboxy-PEG4-phosphonic acid
• CAS NO: 1623791-69-4
• Molecular Formula: C11H23O9P
• Molecular Weight: 330.268681
• Mol File: 1623791-69-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carboxy-PEG4-phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Carboxy-PEG4-phosphonic acid(1623791-69-4)
• EPA Substance Registry System: Carboxy-PEG4-phosphonic acid(1623791-69-4)

Safety Data

• Hazardous Substances Data: 1623791-69-4(Hazardous Substances Data)

Usage

Description

Carboxy-PEG4-phosphonic acid is a PEG (polyethylene glycol) linker with carboxylic acid and phosphonic acid end groups. This unique structure allows it to form stable amide bonds with primary amines through the use of activators like EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide) and HATU (1-(6-((6-((2-Oxo-1,2-dihydro-3H-inden-4-ylidene)methyl)amino)hexyl)oxy)-1,3,5-triazine-2,4-diamine). The hydrophilic PEG chain significantly enhances the water solubility of the compound in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Bioconjugation:
Carboxy-PEG4-phosphonic acid is used as a bioconjugation agent for the formation of stable amide bonds between primary amines and carboxylic acid groups. This application is particularly useful in the creation of conjugates for drug delivery, protein labeling, and the development of diagnostic tools.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Carboxy-PEG4-phosphonic acid is used as a component in drug delivery systems to improve the solubility and bioavailability of hydrophobic drugs. The PEG chain enhances the water solubility, while the carboxylic acid and phosphonic acid ends facilitate the attachment of drug molecules through amide bond formation.
Used in Diagnostics:
Carboxy-PEG4-phosphonic acid is used as a diagnostic tool in the development of imaging agents and contrast agents. The PEG chain can be functionalized with imaging moieties or contrast agents, and the carboxylic acid and phosphonic acid ends can be used to attach targeting ligands, enabling specific detection and imaging of biological processes.
Used in Material Science:
In the field of material science, Carboxy-PEG4-phosphonic acid is used as a building block for the synthesis of hydrogels and other biocompatible materials. The PEG chain provides flexibility and hydrophilicity, while the reactive end groups allow for crosslinking and the incorporation of various functional groups.
Used in Cosmetics:
In the cosmetics industry, Carboxy-PEG4-phosphonic acid is used as an ingredient in skincare products to enhance hydration and improve the skin's moisture retention. The PEG chain's hydrophilic nature helps to bind water, while the carboxylic acid and phosphonic acid ends can interact with other components in the formulation to provide additional benefits.