162698-21-7 Usage
General Description
Ethyl azetidine-2-carboxylate hydrochloride is a chemical compound that is a derivative of azetidine, which is a saturated heterocyclic organic compound. It is commonly used as a reagent in organic synthesis, especially in the preparation of peptides and peptidomimetics. Ethyl azetidine-2-carboxylate hydrochloride is a white crystalline solid that is soluble in water and has a molecular weight of 173.62 g/mol. It is often used as a building block for the synthesis of various pharmaceutical and biologically active compounds due to its unique chemical properties and versatile reactivity. Additionally, it is an important intermediate in the production of drugs, agrochemicals, and other fine chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 162698-21-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,2,6,9 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 162698-21:
(8*1)+(7*6)+(6*2)+(5*6)+(4*9)+(3*8)+(2*2)+(1*1)=157
157 % 10 = 7
So 162698-21-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2.ClH/c1-2-9-6(8)5-3-4-7-5;/h5,7H,2-4H2,1H3;1H
162698-21-7Relevant articles and documents
Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement
Miller, David C.,Lal, Ravi G.,Marchetti, Luca A.,Arnold, Frances H.
supporting information, p. 4739 - 4745 (2022/03/27)
We report enantioselective one-carbon ring expansion of aziridines to make azetidines as a new-to-nature activity of engineered "carbene transferase" enzymes. A laboratory-evolved variant of cytochrome P450BM3, P411-AzetS, not only exerts unparalleled stereocontrol (99:1 er) over a [1,2]-Stevens rearrangement but also overrides the inherent reactivity of aziridinium ylides, cheletropic extrusion of olefins, to perform a [1,2]-Stevens rearrangement. By controlling the fate of the highly reactive aziridinium ylide intermediates, these evolvable biocatalysts promote a transformation which cannot currently be performed using other catalyst classes.
