16286-25-2Relevant articles and documents
Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile
Ruan, Hongli,Lv, Yue,Yu, Shijun,Lv, Chengwei,An, Yue
, p. 1266 - 1274 (2018/08/06)
The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.
Synthesis of zwitterionic salts of pyridinium-meldrum acid and barbiturate through unique four-component reactions
Wang, Qi-Fang,Hui, Li,Hou, Hong,Yan, Chao-Guo
supporting information; experimental part, p. 260 - 265 (2010/08/05)
An efficient synthetic procedure for the preparation of the unusual charge-separated pyridinium-Meldrum acid and N,N-dimethylbarbiturate acid zwitterionic salts was developed though a unique one-pot fourcomponent reaction involving pyridine, aromatic aldehyde, Meldrum acid or N,N-dimethylbarbituric acid, and p-nitrobenzyl bromide in acetonitrile. By varying combinations of four components involving nitrogencontaining heterocycles, we conveniently established reactiveα-halomethylene compounds, aldehydes and β-dicarbonyl compounds a library of zwitterionic salts.
An efficient microwave-assisted synthesis of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives
Tu, Shujiang,Zhu, Xiaotong,Shi, Feng,Zhang, Jinpeng,Zhang, Yan
, p. 837 - 842 (2008/04/12)
(Chemical Equation Presented) Small libraries of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives were synthesized from the condensation-products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using