1629-09-0

Basic information

• Product Name: 3-fluoro-N-phenylbenzamide
• Synonyms: 3-fluoro-N-phenylbenzamide;N-Phenyl 3-fluorobenzamide
• CAS NO: 1629-09-0
• Molecular Formula: C₁₃H₁₀FNO
• Molecular Weight: 215.2230032
• Mol File: 1629-09-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 257.3°Cat760mmHg
• Flash Point: 109.4°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: 1.622
• PKA: 13.02±0.70(Predicted)
• CAS DataBase Reference: 3-fluoro-N-phenylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-N-phenylbenzamide(1629-09-0)
• EPA Substance Registry System: 3-fluoro-N-phenylbenzamide(1629-09-0)

Safety Data

• Hazardous Substances Data: 1629-09-0(Hazardous Substances Data)

Usage

General Description

3-fluoro-N-phenylbenzamide is a chemical compound with the molecular formula C13H10FNO. It is a benzamide derivative with a fluoro substitution at the 3-position of the phenyl ring. 3-fluoro-N-phenylbenzamide has been studied for its potential pharmaceutical properties, particularly in the field of medicinal chemistry and drug development. It is also used as a building block in organic synthesis and chemical research. The presence of the fluoro group in its structure may contribute to its unique chemical and biological properties, making it a valuable tool for further studies and applications.

InChI:InChI=1/C13H10FNO/c14-11-6-4-5-10(9-11)13(16)15-12-7-2-1-3-8-12/h1-9H,(H,15,16)

Upstream product

• 201230-82-2 carbon monoxide 
• 768-35-4 3-fluorophenylboronic acid 
• 62-53-3 aniline 
• 104724-18-7 trimethoxy(3-fluorophenyl)silane 
• 98-80-6 phenylboronic acid 
• 54547-79-4 3-(3-fluorophenyl)-1,4,2-dioxazol-5-one 
• 4930-03-4 phenyl N-phenylcarbamate 
• 448-53-3 tris(3-fluoro phenyl)boroxine 
• 4727-29-1 phthalanilic acid 
• 63197-16-0 5-fluoro-2-phenylisoindoline-1,3-dione 
• 42899-84-3 3-fluoro-N-phenylphthalimide 
• 319-03-9 4-fluorophthalic anhydride 
• 652-39-1 3-fluorophthalic anhydride 
• 17082-12-1 trans-azobenzene 

Downstream Products

• 1629-07-8 2-(3-fluorophenyl)benzo[d]thiazole 
• 1629-18-1 3-fluoro-N-phenylbenzothioamide 
• 1256360-90-3 C₂₃H₁₈FNO₃ 
• 1256360-89-0 C₂₃H₁₈FNO₃ 
• 1207356-68-0 C₁₉H₂₄FNOSi 
• 851295-79-9 3-fluoro-N-phenylbenzenecarboximidoyl chloride 
• 5866-72-8 (3-Fluoro-benzoyl)-phenyl-carbamic acid isopropyl ester 

Relevant articles and documents

Visible-Light-Promoted Iron-Catalyzed N-Arylation of Dioxazolones with Arylboronic Acids

A visible-light-promoted and simple iron salt-catalyzed N-arylation was achieved efficiently under external photosensitizer-free conditions. Arylboronic acids and bench-stable dioxazolones were used for this cross-coupling reaction. This reaction features high reactivity, wide substrate scope, good functional group tolerance, simple operation procedure, and mild reaction conditions. Preliminary mechanistic investigations were conducted to support a radical pathway. This method may contribute to shift the paradigm of iron-catalyzed C-N bond construction and nitrene transfer chemistry.

Para -Selective copper-catalyzed C(sp2)-H amidation/dimerization of anilides via a radical pathway

Copper-catalyzed amidation/dimerization of anilides via regioselective C(sp2)-H functionalization is achieved. The para-selective amidation is accomplished on the anilide aromatic ring via a radical pathway leading to C-N bond formation in the presence of ammonium persulfate as a radical source/oxidant for the copper catalyst. The developed protocol tolerates a wide range of anilide substrates. The regioselectivity is confirmed by single-crystal X-ray studies.

Rhodium-Catalyzed Synthesis of Amides from Functionalized Blocked Isocyanates

Isocyanates are useful building blocks for the synthesis of amides, although their widespread use has been limited by their high reactivity, which often results in poor functional group tolerance and a propensity to oligomerize. Herein, a rhodium-catalyzed synthesis of amides is described coupling boroxines with blocked (masked) isocyanates. The success of the reaction hinges on the ability to form both the isocyanate and the organorhodium intermediates in situ. Relying on masked isocyanate precursors and on the high reactivity of the organorhodium intermediate results in broad functional group tolerance, including protic nucleophilic groups such as amines, anilines, and alcohols.