1630963-20-0Relevant articles and documents
Synthesis and antibacterial activity of novel levofloxacin analogues
Zhang, Tong-Xin,Zhang, Wei-Xi,Zhu, Hua-Jun,Liang, Long,Cheng, Zhi-Peng,Luo, Mei-Ming
, p. 2344 - 2350 (2014/06/09)
To search for new fluoroquinolones with better biological activities, twenty-six levofloxacin analogues were designed, synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative bacterias. The results indicated that most compounds tested in this study exhibited comparable or better antimicrobial activity than levofloxacin as reference drug. Among these compounds, ZY6a was the most active compound against Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa, its activity was found to be 2 to 16 times better than levofloxacin.
