16317-69-4

Basic information

• Product Name: minoxidil
• Synonyms: 6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide; 2,4-Diamino-6-piperidino-pyrimidine-3-oxide; (2E)-6-amino-2-imino-4-(piperidin-1-yl)pyrimidin-1(2H)-ol; 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide
• CAS NO: 16317-69-4
• Molecular Formula: C₉H₁₅N₅O
• Molecular Weight: 209.2483
• EINECS: 253-874-2
• Mol File: 16317-69-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 544.931°C at 760 mmHg
• Flash Point: 283.364°C
• Density: 1.521g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.724
• CAS DataBase Reference: minoxidil(CAS DataBase Reference)
• NIST Chemistry Reference: minoxidil(16317-69-4)
• EPA Substance Registry System: minoxidil(16317-69-4)

Safety Data

• Hazardous Substances Data: 16317-69-4(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 113674-67-2 6-amino-1,2-dihydro-1-acetoxy-2-imino-4-chloropyrimidine 
• 34960-71-9 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-chloropyrimidine 

Relevant articles and documents

Synthesis and purification method for minoxidil

The invention discloses a synthesis and purification method for minoxidil, belonging to the field of chemical synthesis. The method comprises the following steps: with 2,4-diamino-6-chloropyridine as a raw material, carrying out a two-step reaction of low-temperature oxidation and condensation under the condition of alkali catalysis so as to obtain a crude minoxidil product, and carrying out purification through processes like polar solvent crystallization and active carbon decolorization so as to obtain a purified minoxidilum product. The purified minoxidilum product has a purity up to 99.7%; and the preparation method has simple and convenient operation and is applicable to industrial production.