163209-93-6Relevant articles and documents
Synthesis of arrays using low molecular weight MPEG-assisted mitsunobu reaction
Figlus, Marek,Wellaway, Natalie,Cooper, Anthony W. J.,Sollis, Steven L.,Hartley, Richard C.
experimental part, p. 280 - 285 (2011/06/25)
Triphenylphosphine tagged with a short poly(ethyleneglycol)-ω- monomethyl ether chain (light MPEG, 10-16 ethylenoxy units, MTPP-G2) and an MPEG-tagged version of diethyl azodicarboxylate (MDEAD) have been used to prepare a 20 member library of esters, ethers, and sulfonamides, with cLogP?s in the range of 1.4-5.7 on a 0.1 mmol scale. Removal of MPEG-tagged side products was achieved by MPEG-assisted solid-phase extraction (MSPE) on prepacked silica columns to give the products in good yield and high purity.
Fibrinogen receptor antagonists
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, (2008/06/13)
Novel fibrinogen receptor antagonists of the formula: are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.