163428-90-8

Basic information

• Product Name: 3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE
• Synonyms: 3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE;3,4-Dimethoxyphenylglyoxal hydrate 95%;3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE , DRY WT. BASIS;3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE, 98%, DRY WT BASIS;1-(3,4-dimethoxyphenyl)-2,2-dihydroxyEthanone;3,4-Dimethoxyphenylglyoxalhydrate95%
• CAS NO: 163428-90-8
• Molecular Formula: C₁₀H₁₂O₅
• Molecular Weight: 212.2
• EINECS: -0
• Mol File: 163428-90-8.mol
• Article Data: 22

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 387 °C at 760 mmHg
• Flash Point: 187.9 °C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0.000761mmHg at 25°C
• Refractive Index: 1.511
• PKA: 10.88±0.41(Predicted)
• BRN: 3092619
• CAS DataBase Reference: 3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE(163428-90-8)
• EPA Substance Registry System: 3,4-DIMETHOXYPHENYLGLYOXAL HYDRATE(163428-90-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 163428-90-8(Hazardous Substances Data)

Usage

General Description

3,4-Dimethoxyphenylglyoxal hydrate is a chemical compound used often in scientific study and experimentation. It is an organic compound noted for properties including being a hydrate and having two methoxy groups. Given its specification as a phenylglyoxal, it contains a phenyl group, includes a glyoxal (part of the Aldehyde group), which adds to its varied uses in chemical synthesis. Key uses include acting as a reagent in various chemical reactions and studies, which can include the study of RNA and DNA. Its molecular formula is C9H10O5, and despite its potential hazards, if handled safely and responsibly, it can be effectively used in a laboratory setting.

InChI:InChI=1/C10H10O4/c1-13-9-4-3-7(8(12)6-11)5-10(9)14-2/h3-6H,1-2H3

Upstream product

• 15462-03-0 3',4'-dimethoxyphenylglyoxal 
• 91-16-7 1,2-dimethoxybenzene 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 15462-03-0 3',4'-dimethoxyphenylglyoxal 
• 1060798-54-0 3-(3',4'-dimethoxybenzoyl)cyclopropane-1,1,2,2-tetracarbonitrile 
• 1361298-25-0 8-bromo-2-(3,4-dimethoxyphenyl)pyrido[3,4-b]pyrazine 
• 1361298-32-9 N-[2-(3,4-dimethoxyphenyl)pyrido[3,4-b]pyrazin-8-yl]benzophenone imine 
• 1361298-37-4 8-amino-2-(3,4-dimethoxyphenyl)pyrido[3,4-b]pyrazine 

Relevant articles and documents

One-pot, three-component synthesis of polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridine and benzo[g]pyrazolo[3,4-b]quinoline derivatives in the presence of silver nanoparticles (AgNPs)

An efficient and straightforward protocol for one-pot, three-component reaction of aryl glyoxal monohydrates 1a-h, 5-amino-1-aryl-3-methylpyrazoles 2a,b and 4-hydroxyquinoline-2(1H)-one (3) or 2-hydroxy-1,4-naphthoquinone (4) using silver nanoparticles (AgNPs) as a high performance nanocatalyst in H2O/EtOH at 60°C afforded the corresponding polyfunctionalized benzo[h]pyrazolo[3,4-b][1,6]naphthyridines 5a-h and benzo[g]pyrazolo[3,4-b]quinolines 6a-i, respectively. Excellent catalytic activity, high yields, employing green media and green nanocatalyst, cost-effective and simple procedure are some notable advantages of using AgNPs as a noble metal nanocatalyst in this synthetic strategy. The structures of fused heterocycles were confirmed by their Fourier transform infrared, proton nuclear magnetic resonance (1H-NMR), and 13C-NMR spectral data and microanalysis.

A simple protocol for the green synthesis of a new series of pyrimido[4,5b][1,6]naphthyridines in the presence of silver nanoparticles (AgNPs)

Eight polyfunctionalized pyrimidonaphthyridine derivatives has been synthesized, in 79-92% yields, via the one-pot, three-component reaction of aryl glyoxal monohydrates, 6-aminouracil and 4-hydroxyquinolin-2(1H)-one in H2O/EtOH in the presence of AgNPs under mild conditions. In this work colloidal AgNPs acts as an efficient, economical, green nanocatalyst, leading to a simple method of preparation.

One-pot, Three-component Synthesis of a New Series of 2-Amino-4-aroyl-5-oxo-5,6-dihydro-2H-pyrano[3,2-c]quinoline-3-carbonitrile in the Presence of SBA-15 as a Nanocatalyst

One-pot, three-component reaction of arylglyoxals, malononitrile and 4-hydroxyquinolin-2(1H)-one in the presence of SBA-15 as a nanocatalyst and using green solvent systems under various temperatures afforded the 2-amino-4-aroyl-5-oxo-5,6-dihydro-2H-pyrano[3,2-c]quinoline-3-carbonitrile derivatives. The best yield (70-96%) were obtained using 20% mol of SBA-15 as a nanocatalyst in H2O/EtOH (1:1) at 80 °C. The simplicity of work up procedure, using green solvent system, and good to excellent yields of products are the main advantages of this synthetic strategy.