163437-14-7

Basic information

• Product Name: FMOC-MET(O2)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE SULFONE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-METHIONINESULFON;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-METHIONINESULFONE;N-ALPHA-FMOC-L-METHIONINE-SULFONE;FMOC-L-METHIONINE-SULFONE;FMOC-L-MET(O2)-OH;FMOC-METHIONINE(O2)-OH;FMOC-MET(O2)-OH
• CAS NO: 163437-14-7
• Molecular Formula: C20H21NO6S
• Molecular Weight: 403.45
• Mol File: 163437-14-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 709.476 °C at 760 mmHg
• Flash Point: 382.877 °C
• Appearance: White/Powder
• Density: 1.359
• Storage Temp.: Store at RT.
• PKA: 3.52±0.10(Predicted)
• CAS DataBase Reference: FMOC-MET(O2)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-MET(O2)-OH(163437-14-7)
• EPA Substance Registry System: FMOC-MET(O2)-OH(163437-14-7)

Safety Data

• WGK Germany: WGK 2 water endangering
• Hazardous Substances Data: 163437-14-7(Hazardous Substances Data)

Usage

Description

FMOC-MET(O2)-OH, also known as FMOC-Met (O2)-OH, is the N-alpha protected form of L-methionine mediated by the FMOC group (9-Fluorenylmethyloxycarbonyl). It is a white powder that serves as a crucial building block in peptide synthesis, particularly for the solid phase synthesis of ubiquitin C-hydrazide and the creation of novel cyclic peptides with pharmacological effects.

Uses

Used in Pharmaceutical Industry:
FMOC-MET(O2)-OH is used as a building block for peptide synthesis, specifically in the solid phase synthesis of ubiquitin C-hydrazide. This application is essential for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Inflammatory Disease Treatment:
FMOC-MET(O2)-OH is used as a component in the synthesis of novel cyclic peptides with pharmacological effects, particularly for the treatment of inflammatory diseases. Its incorporation into these peptides can contribute to the development of new treatments for various inflammatory conditions.
Used in Peptide Research and Development:
FMOC-MET(O2)-OH is used as a research tool in the field of peptide chemistry, allowing scientists to explore new peptide sequences and structures with potential applications in medicine and biotechnology. Its versatility as a building block enables the creation of a wide range of peptide-based compounds for various purposes.

References

http://www.sigmaaldrich.com/technical-documents/articles/chemfiles/natural-amino-acid.html https://www.iris-biotech.de/de/faa1490/Anderson, S. N., et al. "Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase."Journal of Biomolecular Screening 9.2(2004):112-121. http://web.b.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=09707077&AN=103358230&=iEFjDXbrcrGANWWK7vpLdmsN8yhCmNraNdm1aLMwCgXjuCpr9xSGhioVTsYZqXmo5JtrShPp2WNBkVHpx75ovQ%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d09707077%26AN%3d103358230 http://www.google.com/patents/US6511961