1635-28-5

Basic information

• Product Name: 2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE
• Synonyms: 2-(DIMETHYLAMINO)-4-HYDROXYPYRIMIDINE;2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE;4(1H)-Pyrimidinone, 2-(dimethylamino)- (9CI);2-(DiMethylaMino)pyriMidin-4(1H)-one
• CAS NO: 1635-28-5
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.16
• Product Categories: PYRIMIDINE
• Mol File: 1635-28-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 286.5 °C at 760 mmHg
• Flash Point: 127 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE(1635-28-5)
• EPA Substance Registry System: 2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE(1635-28-5)

Safety Data

• Hazardous Substances Data: 1635-28-5(Hazardous Substances Data)

Usage

General Description

2-(dimethylamino)-4(1H)-pyrimidinone, also known as DMADP, is a chemical compound with the molecular formula C6H9N3O. It is a derivative of pyrimidinone and contains a dimethylamino group. DMADP is primarily used as a building block in the synthesis of pharmaceuticals and agrochemicals, specifically in the production of antiviral and antitumor drugs. It has also been investigated for its potential use in the treatment of Parkinson's disease. DMADP is a white crystalline solid and is soluble in water and organic solvents. Its chemical structure and properties make it an important intermediate for the production of a variety of medicinal and agricultural products.

InChI:InChI=1/C6H9N3O/c1-9(2)6-7-4-3-5(10)8-6/h3-4H,1-2H3,(H,7,8,10)

Upstream product

• 19810-62-9 4-benzyloxy-2-dimethylaminopyrimidine 
• 617-48-1 malic acid 
• 6145-42-2 N,N-Dimethyl-guanidine 

Downstream Products

• 45939-75-1 N²,N²-dimethyl-pyrimidine-2,4,5-triyltriamine 
• 72410-49-2 5-amino-2-dimethylamino-3H-pyrimidin-4-one 
• 5096-84-4 N²,N²-dimethyl-5-nitro-pyrimidine-2,4-diamine 
• 5621-02-3 2-(dimethylamino)pyrimidine 
• 104750-36-9 Dimethyl-(4-{[(E)-methylimino]-phenyl-methyl}-pyrimidin-2-yl)-amine 
• 104750-35-8 (2-Dimethylamino-pyrimidin-4-yl)-methylamino-phenyl-acetonitrile 

Relevant articles and documents

Cyclopalladation in the Periphery of a NHC Ligand as the Crucial Step in the Synthesis of Highly Active Suzuki–Miyaura Cross-Coupling Catalysts

Starting from 2,4-dichloropyrimidine, 4-(2-dialkylamino)pyrimidinyl functionalized mesitylimidazolium chlorides are accessible in a five-step reaction sequence. Two routes leading to palladium NHC complexes derived from these ligands have been worked out: By transmetalation with the corresponding NHC-AgCl complexes, C,N-coordinated palladium(II) complexes can be obtained. Treatment of palladium dichloride with the imidazolium salts in pyridine and in the presence of K2CO3 gives cyclometalated and thus C,C-coordinated compounds. The reactivities of all these compounds were investigated in detail as well as their performance in the catalytic Suzuki–Miyaura cross-coupling reaction. It turned out that the C,C-coordinated derivatives exhibit high catalytic activities in the coupling of arylboronic acids with aryl chlorides, which is consistent with the generally accepted mechanistic ideas on substrate activation.