16355-29-6

Basic information

• Product Name: 6b-Hydroxy Cortisol
• Synonyms: (6b,11b)-6,11,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione;6b-Hydroxyprednisolon;6-hydroxyprednisolone;6β,11β,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;6β-Hydroxyprednisone;Pregna-1,4-diene-3,20-dione, 6,11,17,21-tetrahydroxy-, (6beta,11beta)-;Prednisolone EP Impurity D
• CAS NO: 16355-29-6
• Molecular Formula: C21H28O6
• Molecular Weight: 376.44
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 16355-29-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 248-250?C
• Boiling Point: 618.1°C at 760 mmHg
• Flash Point: 341.6°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 7.3E-18mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.40±0.70(Predicted)
• CAS DataBase Reference: 6b-Hydroxy Cortisol(CAS DataBase Reference)
• NIST Chemistry Reference: 6b-Hydroxy Cortisol(16355-29-6)
• EPA Substance Registry System: 6b-Hydroxy Cortisol(16355-29-6)

Safety Data

• Hazardous Substances Data: 16355-29-6(Hazardous Substances Data)

Usage

Description

6b-Hydroxy Cortisol, also known as 6β-Hydroxy Prednisolone, is a metabolite of Prednisone (P703780) and Prednisolone (Prednisolone EP Impurity D). It is a pale yellow solid with significant chemical properties that make it valuable in various applications.

Uses

Used in Pharmaceutical Industry:
6b-Hydroxy Cortisol is used as a metabolite for [application reason]. As a metabolite of Prednisone, it plays a crucial role in the study and understanding of the metabolic pathways and pharmacokinetics of these medications. This knowledge can be applied to improve drug design, efficacy, and safety in the treatment of various medical conditions.
Used in Research and Development:
6b-Hydroxy Cortisol is used as a research compound for [application reason]. Its unique chemical properties and metabolic relationship with Prednisone make it an essential tool in the development of new drugs and therapies. Researchers can use this compound to study the effects of Prednisone and its metabolites on different biological systems, leading to potential breakthroughs in medicine.
Used in Quality Control and Impurity Profiling:
6b-Hydroxy Cortisol is used as an impurity reference standard for [application reason]. In the pharmaceutical industry, it is essential to ensure the quality and purity of drugs. 6b-Hydroxy Cortisol serves as a reference standard for identifying and quantifying impurities in Prednisolone, helping to maintain the safety and efficacy of the drug.
Used in Analytical Chemistry:
6b-Hydroxy Cortisol is used as an analytical standard for [application reason]. Its distinct chemical properties make it a valuable reference material for various analytical techniques, such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) spectroscopy. These techniques are crucial for the identification, quantification, and structural elucidation of compounds in complex mixtures.

InChI:InChI=1/C21H28O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h3,5,7,12-13,15-16,18,22,24-25,27H,4,6,8-10H2,1-2H3/t12-,13-,15?,16?,18+,19-,20-,21-/m0/s1