1637585-17-1

Basic information

• Product Name: 1-(2-m-tolylthiazol-4-yl)ethanamine
• Synonyms: 1-(2-m-tolylthiazol-4-yl)ethanamine
• CAS NO: 1637585-17-1
• Molecular Weight: 218.323
• Mol File: 1637585-17-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-m-tolylthiazol-4-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-m-tolylthiazol-4-yl)ethanamine(1637585-17-1)
• EPA Substance Registry System: 1-(2-m-tolylthiazol-4-yl)ethanamine(1637585-17-1)

Safety Data

• Hazardous Substances Data: 1637585-17-1(Hazardous Substances Data)

Upstream product

• 1637585-09-1 N-(1-(2-m-tolylthiazol-4-yl)ethyl)butyramide 
• 1637585-01-3 C₁₂H₁₂N₄S 
• 92422-79-2 2-m-tolyl-thiazole-4-carbaldehyde 
• 1637585-05-7 N-(1-(2-m-tolylthiazol-4-yl)ethyl)butyramide 
• 1177474-03-1 1-(2-m-tolylthiazol-4-yl)ethanamine 

Relevant articles and documents

Candida antarctica lipases acting as versatile catalysts for the synthesis of enantiopure (R)- and (S)-1-(2-phenylthiazol-4-yl)ethanamines This paper is dedicated to the anniversary of 95th birthday of Professor Valer Fǎrcǎ?anu.

The synthesis of both enantiomers of four new phenylthiazole-based amines by enantiomer-selective acylation of racemic amines and by hydrolysis of the corresponding racemic amides using lipase B from Candida antarctica (Novozyme 435) as chiral catalyst was performed with good yields and excellent enantioselectivities. In order to prevent the frequently occurring partial racemization of enantiopure amides during chemical hydrolysis to the corresponding (R)-amines, the deprotection of the N-acylated (R)-enantiomers by mild enzymatic hydrolysis with lipase A from C. antarctica immobilized on Celite was also developed.