1639-45-8

Basic information

• Product Name: 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione
• Synonyms: 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione
• CAS NO: 1639-45-8
• Molecular Weight: 390.52
• Mol File: 1639-45-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione(1639-45-8)
• EPA Substance Registry System: 21-acetoxy-17α-hydroxy-5α-pregnane-3,20-dione(1639-45-8)

Safety Data

• Hazardous Substances Data: 1639-45-8(Hazardous Substances Data)

Upstream product

• 640-87-9 cortexolone 21-acetate 

Downstream Products

• 1249-67-8 17α,21-dihydroxypregna-1,4-diene-3,20-dione 21-acetate 
• 56162-38-0 allotetrahydro-11-deoxycolesterol 21-glucuronide 
• 601-01-4 Allo-Tetrahydrodeoxycortisol 
• 312-99-2 17α-21-dihydroxy-5-α-pregnane-3,20-dione 
• 516-41-6 11α,17α,21-trihydroxy-5α-pregnane-3,20-dione 

Relevant articles and documents

The scarlet letter: Reichstein's substance S. A comparison of the angiostatic properties of 5α-tetrahydro S and 5β-tetrahydro S

5β-Tetrahydro-Reichtein's Substance S (3α, 5β-THS) from different sources yielded variable bioassays activity in the chick chorio-allantoic membrane assay system. Physical characterization showed impure products. Synthesis of this compound by two different routes yielded active and inactive 3α,5β-THS. Of the other two epimers, 3β,5β-THS (epi-THS) and 3α,5α-THS (allo-THS), only the latter was active. These results suggest that the impurities present in 3α,5β-THS synthesized by reduction of the α,β-unsaturated ketone of Substance S might be either or both the epi- lallo-epimers (3β,5β-THS and 3α,5α-THS, respectively), with only the latter contributing the positive angiostatic activity to the mixture. Of the two synthetically derived compounds, only the latter was shown to maintain the activity, whereas 3α,5β-THS was not antiangiogenic.