1639-60-7

Basic information

• Product Name: PROPOXYPHENE HYDROCHLORIDE
• Synonyms: DARVON;DEXTROPROPOXYPHENE HYDROCHLORIDE;PROPOXYPHENE HYDROCHLORIDE;(+)-1,2-diphenyl-2-propionoxy-3-methyl-4-dimethylaminobutanehydrochloride;(+)-hlorid;algaphan;(αS)-α-[(1R)-2-(DiMethylaMino)-1-Methylethyl]-α-phenylbenzeneethanol Propanoate Hydrochloride;D-Propoxyphene-d5 HCl
• CAS NO: 1639-60-7
• Molecular Formula: C₂₂H₂₉NO₂*ClH
• Molecular Weight: 375.93
• EINECS: 216-683-5
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Aromatics
• Mol File: 1639-60-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 165-1670C
• Boiling Point: 444 °C at 760 mmHg
• Flash Point: 11 °C
• Appearance: White solid
• Storage Temp.: -20°C Freezer
• Solubility: Very soluble in water, freely soluble in ethanol (96 per cent).
• Water Solubility: 3.7mg/L(25 oC)
• Stability: No data available.
• CAS DataBase Reference: PROPOXYPHENE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PROPOXYPHENE HYDROCHLORIDE(1639-60-7)
• EPA Substance Registry System: PROPOXYPHENE HYDROCHLORIDE(1639-60-7)

Safety Data

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45
• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1639-60-7(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 1639-60-7 differently. You can refer to the following data:
1. Dextropropoxyphene is a controlled substance (opiate). Analgesic (narcotic). The α-dl-and d-diastereoisomers possess marked analgesic activity in contrast to the β-diastereoisomers which are substantially inactive.
2. Dextropropoxyphene is a controlled substance (narcotic)

Brand name

Darvon (Xanodyne); Dolene (Clonmel).

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion: anorexia, ataxia, chronic pulmonary edema, cyanosis, increased body temperature, jaundice, nausea or vomiting, sleep disturbance. Experimental teratogenic and reproductive effects. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also PROPOXYPHENE.

InChI:InChI=1/C22H29NO2.2ClH/c1-5-21(24)25-22(18(2)17-23(3)4,20-14-10-7-11-15-20)16-19-12-8-6-9-13-19;;/h6-15,18H,5,16-17H2,1-4H3;2*1H/t18-,22+;;/m1../s1

Downstream Products

• 24274-73-5 (E)-1,2-diphenyl-2-butene 
• 35947-82-1 Z-1,2-diphenyl-2-butene 
• 76290-86-3 cis-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾ 
• 19928-09-7 trans-4-Dimethylamino-3-methyl-1,2-diphenyl-buten-⁽¹⁾ 

Related news

Semiautomated Assay for the Simultaneous Determination of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) and Paramethasone Acetate in Coated Single Tablets08/02/2019

A semiautomated method for the simultaneous determination of propoxyphene hydrochloride and paramethasone acetate is described for coated tablets. A novel device for the removal and dissolution of tablet coatings is outlined. Solutions are sampled with an automatic sampler at the rate of 20/hr. ...detailed

Mathematical Model for In Vitro Drug Release from Controlled Release Dosage Forms Applied to PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) Pellets08/01/2019

The in vitro release of drugs from controlled-release dosage forms has been studied in terms of a diffusion model. The model has been applied to a pellet formulation containing propoxyphene hydrochloride. It is demonstrated that the model may be used to predict the drug release profile adequatel...detailed

High-pressure liquid chromatographic determination of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) in tablets and capsules07/29/2019

The determination of propoxyphene hydrochloride by gas chromatography (GC) has been examined. Under a number of operating conditions significant on-column decomposition has occurred. The amounts of decomposition have been found to be dependent on sample size, flow-rate, column temperature, liqui...detailed

Neonatal withdrawal symptoms associated with maternal use of PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) (Darvon)07/28/2019

Withdrawal symptoms in a neonate whose mother had been a chronic user of propoxyphene hydrochloride have not, as far as we are aware, been reported. We observed withdrawal symptoms in a neonate at 20 hours of age; the mother had taken propoxyphene hydrochloride regularly for over 3 years prior t...detailed

Left bundle branch block associated with PROPOXYPHENE HYDROCHLORIDE (cas 1639-60-7) poisoning07/26/2019

Described is the case of a patient who developed left bundle branch block following acute propoxyphene hydrochloride overdosage. The left bundle branch block was transient and associated with no permanent sequelae. Previously documented cardiac abnormalities, specific narcotic antagonist therapy...detailed