164082-86-4

Basic information

• Product Name: 1H-Indole, 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-
• CAS NO: 164082-86-4
• Molecular Formula: C18H18ClNO
• Molecular Weight: 299.8
• Mol File: 164082-86-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-(164082-86-4)
• EPA Substance Registry System: 1H-Indole, 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-(164082-86-4)

Safety Data

• Hazardous Substances Data: 164082-86-4(Hazardous Substances Data)

Usage

Indole derivative

A heterocyclic aromatic organic compound

Chlorophenylmethyl group

A chlorine-substituted phenylmethyl group

Ethyl group

A two-carbon alkyl group

Methoxy group

An oxygen-substituted methyl group

Unique chemical properties

Due to the presence of substituents like chlorophenylmethyl, ethyl, and methoxy groups

Potential pharmaceutical applications

Exhibits a range of biological activities

Biological activities

Anticancer, anti-inflammatory, and antimicrobial properties

Pharmacokinetic properties

How the compound is absorbed, distributed, metabolized, and excreted in the body

Pharmacodynamic properties

The compound's effect on the body and its therapeutic potential

Further research and testing

Necessary to understand the potential uses and effects of the compound

Upstream product

• 19500-02-8 2-methyl-3-methoxyaniline 
• 164082-78-4 1-[2-(tert-butoxycarbonylamino)-6-methoxyphenyl]-2-butanone 
• 164082-77-3 tert-butyl (3-methoxy-2-methylphenyl)carbamate 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 164082-79-5 2-Ethyl-4-methoxy-1H-indole 
• 766-80-3 1-bromomethyl-3-chlorobenzene 

Downstream Products

• 164082-87-5 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-alpha-oxo-1H-indole-3-acetamide 
• 172733-11-8 ((3-(2-amino-1,2-dioxoethyl)-1-((3-chlorophenyl)methyl)-2-ethyl-1H-indol-4-yl)oxy)acetic acid methyl ester 
• 1026499-83-1 [1-(3-Chloro-benzyl)-3-chlorooxalyl-2-ethyl-1H-indol-4-yloxy]-acetic acid methyl ester 
• 185501-88-6 [3-Carbamoyl-1-(3-chloro-benzyl)-2-ethyl-1H-indol-4-yloxy]-acetic acid methyl ester 
• 172733-10-7 [[1-[(3-chlorophenyl)methyl]-2-ethyl-1H-indol-4-yl]oxy]acetic acid methyl ester 
• 185501-87-5 1-(3-Chloro-benzyl)-2-ethyl-4-hydroxy-1H-indole-3-carboxylic acid amide 
• 164123-33-5 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-1H-indole-3-acetamide 
• 164179-99-1 1-[(3-chlorophenyl)methyl]-2-ethyl-4-methoxy-alpha-hydroxy-1H-indole-3-acetamide 
• 172733-09-4 1-(3-Chloro-benzyl)-2-ethyl-1H-indol-4-ol 
• 1027853-40-2 [1-(3-Chloro-benzyl)-2-ethyl-4-methoxy-1H-indol-3-yl]-oxo-acetyl chloride 

Relevant articles and documents

1H-INDOLE-3-GLYOXYLAMIDE SPLA2 INHIBITORS

A class of novel 1H-indole-3-glyoxylamides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty adds for treatment of conditions such as septic shock

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.