164104-49-8

Basic information

• Product Name: 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)-
• Synonyms: 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)-;TETRABENAZINE METABOLITE C;(2S,3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol;(2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
• CAS NO: 164104-49-8
• Molecular Formula: C19H29 N O3
• Molecular Weight: 319.44
• Product Categories: Impurities & Metabolites
• Mol File: 164104-49-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 107-108 °C(Solv: hexane (110-54-3))
• Boiling Point: 457.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.75±0.40(Predicted)
• CAS DataBase Reference: 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)-(164104-49-8)
• EPA Substance Registry System: 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)-(164104-49-8)

Safety Data

• Hazardous Substances Data: 164104-49-8(Hazardous Substances Data)

Usage

Description

2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)is a complex organic compound with a unique molecular structure. It belongs to the class of benzoquinolizinols and is characterized by its hexahydro, dimethoxy, and 2-methylpropyl functional groups. The stereochemistry of the compound is defined by the (2S,3S,11bS) configuration, which plays a crucial role in its properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)is used as a Vesicular Monoamine Transporter 2 (VMAT2) inhibitor for its potential therapeutic applications. VMAT2 inhibitors have been found to modulate the levels of monoamines, such as dopamine, serotonin, and norepinephrine, in the brain, making them valuable in the treatment of various neurological and psychiatric disorders.
Used in Asthma Treatment:
In the medical field, 2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)is used as a treatment for asthma. Its mechanism of action may involve the modulation of monoamines, which can help alleviate symptoms associated with asthma, such as bronchoconstriction and inflammation.
Used in Anxiety Treatment:
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)is also used in the treatment of anxiety disorders. By acting as a VMAT2 inhibitor, it can help regulate the levels of monoamines in the brain, which are known to play a role in mood regulation and anxiety. This can lead to a reduction in anxiety symptoms and an improvement in the overall well-being of patients.
Used in Dementia Treatment:
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2S,3S,11bS)is utilized in the management of dementia and related cognitive disorders. Its ability to modulate monoamines may help improve cognitive function and slow down the progression of dementia in affected individuals.