1643440-91-8

Basic information

• Product Name: 3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE
• Synonyms: 3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE;3-Bromobenzamidoxime;(Z)-3-bromo-N'-hydroxybenzimidamide
• CAS NO: 1643440-91-8
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.05
• Mol File: 1643440-91-8.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 307.5±44.0 °C(Predicted)
• Appearance: /
• Density: 1.68±0.1 g/cm3(Predicted)
• PKA: 13.97±0.50(Predicted)
• CAS DataBase Reference: 3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(1643440-91-8)
• EPA Substance Registry System: 3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(1643440-91-8)

Safety Data

• Hazardous Substances Data: 1643440-91-8(Hazardous Substances Data)

Usage

Description

3-Bromo-N'-hydroxybenzenecarboximide is an amide derivative that features a bromine atom and a hydroxyl group attached to a benzene ring. This chemical compound serves as a versatile building block in the creation of new substances due to its chemical properties, making it suitable for a range of applications in the production of pharmaceuticals and other chemical products.

Uses

Used in Pharmaceutical Industry:
3-Bromo-N'-hydroxybenzenecarboximide is used as a key intermediate in the synthesis of pharmaceutical drugs. Its unique structure allows it to react with other compounds, facilitating the development of a variety of medicinal products.
Used in Agrochemical Industry:
3-BROMO-N'-HYDROXYBENZENECARBOXIMIDAMIDE also finds application in the agrochemical sector, where it is utilized in the synthesis of agrochemicals. Its reactivity and structural features make it a valuable component in creating effective products for agricultural use.
Used in Organic Synthesis:
3-Bromo-N'-hydroxybenzenecarboximide is used as an intermediate in organic synthesis. Its ability to form a variety of products through reactions with other compounds makes it a useful substance in the creation of new chemical entities for diverse applications.

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 51873-95-1 3-bromobenzaldehyde oxime 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 160377-57-1 3-(3-bromophenyl)-5-methyl-1,2,4-oxadiazole 

Relevant articles and documents

An efficient one-pot synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles under solvent-free conditions

An efficient and simple synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with alkyl 2,2-dialkoxyacetates under solvent-free conditions

SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

A simple, mild and practical cascade process for the direct conversion of aldehydes to cyanamides was developed featuring a wide substrate scope and great functional group tolerability. This method allows for transformations of readily available, inexpensive, and abundant aldehydes to highly valuable cyanamides in a pot, atom, and step-economical manner with a green nitrogen source. This protocol will serve as a robust tool for the installation of the cyanamide moiety in various complicated molecules.

1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.