164916-63-6

Basic information

• Product Name: CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID
• Synonyms: CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID;3,4-Pyrrolidinedicarboxylic acid, 1-(phenylMethyl)-, cis-;(3R,4S)-1-Benzylpyrrolidine-3,4-dicarboxylic acid;cis-1-Benzylpyrrolidine-3,4-dicarboxylic acid
• CAS NO: 164916-63-6
• Molecular Formula: C13H15NO4
• Molecular Weight: 249.26
• Product Categories: pharmacetical
• Mol File: 164916-63-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 460°Cat760mmHg
• Flash Point: 232°C
• Appearance: /
• Density: 1.365g/cm³
• Vapor Pressure: 2.94E-09mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: 2-8°C
• CAS DataBase Reference: CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID(164916-63-6)
• EPA Substance Registry System: CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID(164916-63-6)

Safety Data

• Hazardous Substances Data: 164916-63-6(Hazardous Substances Data)

Usage

General Description

CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID, also known as Cis-Bz-Pip-dicarboxylic acid, is a chemical compound with the molecular formula C15H17NO4. It is a derivative of pyrrolidine and dicarboxylic acid and is commonly used in the pharmaceutical industry as a building block for various drugs and medications. CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLIC ACID is known for its potential therapeutic properties, particularly in the treatment of central nervous system disorders. It is also used in the synthesis of various organic compounds and pharmaceutical intermediates due to its versatile chemical nature and properties.

InChI:InChI=1/C13H15NO4/c15-12(16)10-7-14(8-11(10)13(17)18)6-9-4-2-1-3-5-9/h1-5,10-11H,6-8H2,(H,15,16)(H,17,18)/t10-,11+

Upstream product

• 87813-06-7 dimethyl 1-benzylpyrrolidine-3,4-dicarboxylate 

Downstream Products

• 1221289-17-3 cis-5-benzyltetrahydro-1H-furo[3,4-c]pyrrole-1,3(3aH)-dione 

Relevant articles and documents

Synthesis and biological activity of Δ-5,6-norcantharimides: importance of the 5,6-bridge

Cantharidin (1) and norcantharidin (2) are potent protein phosphatase 1 and 2A inhibitors that also display high levels of anticancer activity against a broad range of tumor cells lines. Surprisingly, Δ-5,6-ethyl norcantharidin (3, cis-tetrahydrofurano[3,4-c]furan-1,3-dione) displays neither phosphatase inhibition nor anticancer activity. This suggests that the 5,6-ethyl bridge is pivotal to both anti-cancer and protein phosphatase activity. Additionally bioisosteric replacement of the ethereal oxygen has no effect on biological activity nor does modification of the anhydride moiety. Unlike the parent norcantharidin, anhydride ring opening has no effect on either protein phosphatase inhibition or anti-cancer activity. Additionally, this work highlights the discovery of the octyl substituted, cis-5-benzyl-2-hexyltetrahydro-2H,3aH-pyrrolo[3,4-c]pyrrole-1,3-dione, 9p, and the octyl substituted, cis-octyltetrahydro-5H-furo[3,4-c]pyrrole-4,6-dione, 8p, as two new cytotoxic agents which are equipotent (9p) with, and more potent (8p) than norcantharidin. Crown Copyright