165894-25-7Relevant articles and documents
Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists
Tora, George,Degnan, Andrew P.,Conway, Charles M.,Kostich, Walter A.,Davis, Carl D.,Pin, Sokhom S.,Schartman, Richard,Xu, Cen,Widmann, Kimberly A.,Macor, John E.,Dubowchik, Gene M.
, p. 5684 - 5688 (2013)
Several new potent CGRP receptor antagonists have been prepared in which the amide bond of lead compound 1 has been replaced by bioisosteric imidazole moieties. Substitution at N-1 of the imidazole was optimized to afford compounds with comparable potency