166402-15-9

Basic information

• Product Name: 2-Chloro-3-phenyl-6-trifluoromethyl-8-aminoquinoxaline
• Synonyms: 2-Chloro-3-phenyl-6-trifluoromethyl-8-aminoquinoxaline
• CAS NO: 166402-15-9
• Molecular Weight: 323.705
• Mol File: 166402-15-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Chloro-3-phenyl-6-trifluoromethyl-8-aminoquinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-phenyl-6-trifluoromethyl-8-aminoquinoxaline(166402-15-9)
• EPA Substance Registry System: 2-Chloro-3-phenyl-6-trifluoromethyl-8-aminoquinoxaline(166402-15-9)

Safety Data

• Hazardous Substances Data: 166402-15-9(Hazardous Substances Data)

Upstream product

• 17661-60-8 5-Trifluoromethyl-benzene-1,2,3-triamine 
• 166402-53-5 3-Phenyl-6-trifluoromethylquinoxaline-2(1H)-one 

Relevant articles and documents

Quinoxaline chemistry. Part 4. 2-(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity

Thirty-five quinoxalines bearing a substituted amiline group on position 2 and various substituents on positions 3, 6, 7 and 8 were prepared in order to evaluate in vitro anticancer activity. Structural elucidation of some isomeric quinoxalinones formed by ring closure of 4-substituted-1,2-diaminobenzenes with dicarbonyl compounds was achieved by comparison with one isomer coming from an unambiguous independent route. Preliminary in vitro screening at NCI showed that many compounds exhibited a moderate to strong growth inhibition activity on various cell lines between 10-5 and 10-4 molar concentrations.