166588-80-3

Basic information

• Product Name: 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-2-naphthalen-1-yl-ethanone
• CAS NO: 166588-80-3
• Molecular Weight: 422.57
• Mol File: 166588-80-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-2-naphthalen-1-yl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-2-naphthalen-1-yl-ethanone(166588-80-3)
• EPA Substance Registry System: 1-((4R,7S)-7-Isopropyl-4-methyl-3-phenyl-4,5,6,7-tetrahydro-indazol-2-yl)-2-naphthalen-1-yl-ethanone(166588-80-3)

Safety Data

• Hazardous Substances Data: 166588-80-3(Hazardous Substances Data)

Upstream product

• 5121-00-6 naphthalen-1-yl-acetyl chloride 
• 155095-10-6 (4R,7S)-3-phenyl-4-methyl-7-isopropyl-4,5,6,7-tetrahydro-1H-indazole 
• 155095-12-8 (3R,6S)-2-Benzoyl-3-methyl-6-isopropylcyclohexanone 
• 98-88-4 benzoyl chloride 
• 10458-14-7 (2R,5S)-menthone 

Relevant articles and documents

Diastereoselective α-alkylation of 2-acyl-3-phenyl-l-menthopyrazoles

N-Acylpyrazoles were α-alkylated in good yields by the treatment with alkyl halides after metalation with LDA or LiHMDS. In the case of chiral N-acylpyrazoles, e.g., 2-acyl-3-phenyl-l-menthopyrazoles (4), the α-alkylation was highly diastereoselective. The subsequent α-alkylation products could be converted into esters in good yield in the presence of BF3·OEt2 without the loss of the optical purity.