16669-06-0 Usage
Description
2-((8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)acetonitrile is a complex organic compound with a unique molecular structure. It is characterized by its 17-membered ring system and multiple functional groups, including hydroxyl and nitrile groups. 2-((8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)acetonitrile is an impurity of Dienogest (D441870), a derivative of 19-Nortestosterone, and is used in combination with estrogen as an oral contraceptive.
Uses
Used in Pharmaceutical Industry:
2-((8R,9S,13S,14S,17R)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl)acetonitrile is used as a progestogen in the pharmaceutical industry. It is an impurity of Dienogest, which is a synthetic progestin used in combination with estrogen as an oral contraceptive. Dienogest helps regulate the menstrual cycle and prevents ovulation, making it an essential component in birth control pills.
Check Digit Verification of cas no
The CAS Registry Mumber 16669-06-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,6,6 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16669-06:
(7*1)+(6*6)+(5*6)+(4*6)+(3*9)+(2*0)+(1*6)=130
130 % 10 = 0
So 16669-06-0 is a valid CAS Registry Number.
16669-06-0Relevant articles and documents
Nitrile hydratase from Rhodococcus erythropolis: Metabolization of steroidal compounds with a nitrile group
Kaufmann, Guenter,Dautzenberg, Horst,Henkel, Harry,Mueller, Gerd,Schaefer, Thomas,Undeutsch, Bernd,Oettel, Michael
, p. 535 - 540 (1999)
The progestin dienogest (17α-cyanomethyl-17β-hydroxy-estra-4,9-dien-3-one) was metabolized by the nitrile hydratase-containing microorganism Rhodococcus erythropolis. An enzymatic hydrolysis of the nitrile group at the 17α-side chain was intended to obtain novel derivatives and to test them for progesterone receptor affinity. In contrast to the rapid enzymatic hydrolysis of nonsteroidal nitriles, the nitrile group of dienogest was cleaved very slowly. The dominant reaction was an aromatization of ring A. After prolonged fermentation, the 17α-acetamido derivatives of estradiol and of 9(11)-dehydroestradiol were formed. Three of the metabolites were also prepared synthetically. They were tested for hormonal activity by assessing their binding to progesterone and estrogen receptors in vitro. Neither the aromatized 17α-acetamido derivatives nor the dienogest derivative 17α-acetamido-17β-hydroxy-estra-4,9-dien-3-one, which was prepared synthetically only, exhibited affinity for the progesterone receptor. Copyright (C) 1999 Elsevier Science Inc.
