166740-44-9

Basic information

• Product Name: 2-chloro-5-cyclopropylpyriMidine
• Synonyms: 2-chloro-5-cyclopropylpyriMidine
• CAS NO: 166740-44-9
• Molecular Formula: C₇H₇ClN₂
• Molecular Weight: 154.59688
• EINECS: -0
• Mol File: 166740-44-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 2-chloro-5-cyclopropylpyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-cyclopropylpyriMidine(166740-44-9)
• EPA Substance Registry System: 2-chloro-5-cyclopropylpyriMidine(166740-44-9)

Safety Data

• Hazardous Substances Data: 166740-44-9(Hazardous Substances Data)

Usage

General Description

2-chloro-5-cyclopropylpyrimidine is a chemical compound with the formula C7H7ClN2. It is a heterocyclic compound containing a pyrimidine ring with a chlorine atom at position 2 and a cyclopropyl group at position 5. 2-chloro-5-cyclopropylpyrimidine is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is known for its role as a building block in the production of various drugs, including antiviral and antitumor agents. Additionally, it has been studied for its potential use as a herbicide and fungicide. Due to its versatile applications in the pharmaceutical and agricultural industries, 2-chloro-5-cyclopropylpyrimidine is a valuable chemical compound with significant industrial importance.

Upstream product

• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 411235-57-9 cyclopropylboronic acid 

Downstream Products

• 1104449-65-1 4-(1-(5-cyclopropylpyrimidin-2-yl)piperidin-4-yloxy)-5-methyl-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 
• 1104449-74-2 4-(1-(5-cyclopropylpyrimidin-2-yl)piperidin-4-yloxy)-6-methyl-1-(4-(methylsulfonyl)phenyl)pyridin-2(1H)-one 

Relevant articles and documents

GPR139 RECEPTOR MODULATORS

Compounds are provided that modulate the GPR139 receptor, compositions containing the same, and to methods of their preparation and use for treatment of a malcondition wherein modulation of the GPR139 receptor is medically indicated or beneficial. Such compounds have the structure of Formula (X) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, R3, R4, R9, R10, R11, and R12, Q5, Q6, Q7 and Q8 are as defined herein.

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to novel heteroaryl compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.

SUBSTITUTED 2-AZABICYCLO[3.1.1]HEPTANE AND 2-AZABICYCLO[3.2.1]OCTANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

There is provided a compound of formula (I), wherein L1 to L3, R1 to R4, X, A and B have meanings given in the description, and pharmaceutically acceptable salts, solvates and prodrugs thereof, which compounds are useful as antagonists of the orexin-1 and orexin-2 receptors or as selective antagonists of the orexin-1 receptor, and thus, in particular, in the treatment or prevention of inter alia substance dependence, addiction, anxiety disorders, panic disorders, binge eating, compulsive disorders, impulse control disorders, cognitive impairment and Alzheimer's disease.