167264-32-6Relevant articles and documents
1-(2-BENZIMIDAZOLYL)-1,5-DIAZACYCLOOCTANE COMPOUNDS
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, (2008/06/13)
1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds represented by the formula: STR1 wherein X represents a hydrogen atom or a halogen atom; Y represents a covalent bond, a straight-or branched-chain alkylene group having 1 to 6 carbon atoms, or a straight-or branched-chain alkenylene group having 2 to 6 carbon atoms; R represents a hydrogen atom, or a straight-or branched-chain alkyl group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The compounds represented above are novel potent and long-lasting histamine HI-receptor antagonist with less-topical irritation, and can be topically administered by inhalation for the treatment of bronchial asthma.