167371-60-0Relevant articles and documents
Synthesis and structure-activity relationship of a new series of potent angiotensin II receptor antagonists: Pyrazolo[1,5-α]pyrimidine derivatives
Shiota, Takeshi,Yamamori, Teruo,Sakai, Katsunori,Kiyokawa, Mitsugu,Honma, Tsunetoshi,Ogawa, Masayoshi,Hayashi, Kunio,Ishizuka, Natsuki,Matsumura, Ken-Ichi,Hara, Mariko,Fujimoto, Masafumi,Kawabata, Tomoji,Nakajima, Shigeyuki
, p. 928 - 938 (2007/10/03)
We have already reported 7-oxo-4,7-dihydropyrazolo[1,5-α]pyrimidine-3- carboxylic acid derivatives, which are potent in vitro angiotensin II (AII) antagonists, but have no oral antihypertensive activity. Removal of the carboxylic acid and replacement of t