16764-13-9

Basic information

• Product Name: Benzeneethanol, 2-nitro-a-phenyl-
• CAS NO: 16764-13-9
• Molecular Formula: C14H13NO3
• Molecular Weight: 243.262
• Mol File: 16764-13-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzeneethanol, 2-nitro-a-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, 2-nitro-a-phenyl-(16764-13-9)
• EPA Substance Registry System: Benzeneethanol, 2-nitro-a-phenyl-(16764-13-9)

Safety Data

• Hazardous Substances Data: 16764-13-9(Hazardous Substances Data)

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 100-52-7 benzaldehyde 
• 17876-76-5 trimethyl(2-nitrobenzyl)silane 
• 4212-33-3 2-(2-nitrophenyl)-1-phenylethanone 

Downstream Products

• 1308803-47-5 2-(2-nitrophenyl)-1-phenylpropen-1-one 
• 835893-34-0 1-deuterio-1-phenyl-2-(2-nitrophenyl)ethene 
• 209979-45-3 2-(2-deuterio-2-phenylethyl)phenyl azide 
• 835893-33-9 1-deuterio-1-phenyl-2-(2-nitrophenyl)ethanol 
• 835893-35-1 2-(2-deuterio-2-phenylethyl)aniline 
• 26211-73-4 (2-methyl-1H-indol-3-yl)phenylmethanone 
• 1429196-08-6 3-methyl-4-(2-nitrophenyl)-5-phenylisoxazole 
• 149913-91-7 allyl α-phenyl-2-<(allyloxycarbonyl)amino>phenethyl carbonate 
• 149913-87-1 allyl α-phenyl-2-aminophenethyl carbonate 
• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Synthesis of 2-substituted indole with Hantzsch ester catalyzed by palladium

An efficient reductive cyclization of o-nitrobenzyl ketone compounds was achieved by using a Hantzsch 1,4-dihydropyridine ester as a biomimetic reducing agent in the presence of catalytic palladium on carbon. 2-Substituted indoles were obtained in good yields. Investigation of the mechanism suggests that palladium hydride promotes the reduction of nitro group, and acetic acid was beneficial for the loss of water to produce the intended product. This reaction system can not only broaden the use of Hantzsch 1,4-dihydropyridine ester, but it also provides a novel approach for preparing indole compounds.

Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1 H-indoles, and quinolin-4(1 H)-ones

Reductive heterocycle-heterocycle (heterocycle → heterocycle; H-H) transformations that give 4-aminoquinolines, 3-acylindoles, and quinolin-4(1H)-ones from 2-nitrophenyl substituted isoxazoles are reported. When this methodology is applied to 3,5-, 4,5-,

Mechanistic studies of intramolecular CH insertion reaction of arylnitrenes: Isotope effect, configurational purity and radical clock studies

In order to reveal the mechanism of the intramolecular CH insertion of arylnitrenes, three experiments were carried out: measurement of isotope effects, determination of the extent of configurational retention and radical clock studies. Irradiation of the deuterium-substituted azide 4-d in an inert solvent exclusively afforded the indolines 5-h and 5-d, in which the kinetic isotope effect kH/kD on the intramolecular CH insertion of the nitrene was evaluated as 12.6-14.7 at room temperature. A chiral Chromatographic analysis of the indoline 11 obtained from the optically active azide (S)-6 revealed that the enantiomeric purity of the starting azide was almost completely lost during the intramolecular CH insertion of the photolytically generated nitrene (enantiomeric excess 10%). The thermolysis of the azide 7 at 180°C mainly gave a mixture of the cyclopropyl ring-opened products 20-22, together with the intramolecular CH insertion product with an intact cyclopropyl ring 19. On the basis of these observations, we concluded that the intramolecular CH insertion of the nitrene proceeds primarily by the hydrogen abstraction-recombination mechanism. We propose, however, a small contribution of the concerted mechanism to the intramolecular CH insertion, based on the solvent dependence of the isotope effect and the extent of the configurational retention. Copyright