16778-16-8Relevant articles and documents
From insertion to multicomponent coupling: Temperature dependent reactions of arynes with aliphatic alcohols
Thangaraj, Manikandan,Bhojgude, Sachin Suresh,Mane, Manoj V.,Biju, Akkattu T.
supporting information, p. 1665 - 1668 (2016/01/30)
The temperature dependent selectivity switch in the reaction of arynes with aliphatic alcohols in THF has been reported. At -20°C, arynes smoothly insert into the O-H bond of alcohols to form alkyl aryl ethers. Interestingly, at 60°C, a highly selective multicomponent coupling occurs with the solvent THF acting as the nucleophilic trigger affording (4-(alkoxy)butoxy)arenes.
