167887-37-8Relevant articles and documents
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jourdan, Jean-Pierre,Since, Marc,El Kihel, La?la,Lecoutey, Cédric,Corvaisier, Sophie,Legay, Rémi,Sopkova-De Oliveira Santos, Jana,Cresteil, Thierry,Malzert-Fréon, Aurélie,Rochais, Christophe,Dallemagne, Patrick
, p. 365 - 379 (2016)
This work describes the synthesis and the biological evaluation of novel benzylidenephenylpyrrolizinones as potential antioxidant, metal chelating or amyloid β (βA) aggregation inhibitors. Some derivatives exhibited interesting results in regard to several of the performed evaluations and appear as valuable Multi-Target Directed Ligands with potential therapeutic interest in Alzheimer's disease. Among them, compound 29 particularly appears as a valuable radical and NO scavenger, a Cu(II) and Fe(II) chelating agent and exhibits moderate βA aggregation inhibition properties. These activities, associated to a good predictive bioavailability and a lack of cytotoxicity, design it as a promising hit for further in vivo investigation.