167963-62-4

Basic information

• Product Name: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-(3-phenylsulfanyl-propyl) ester
• Synonyms: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-(3-phenylsulfanyl-propyl) ester
• CAS NO: 167963-62-4
• Molecular Weight: 521.594
• Mol File: 167963-62-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-(3-phenylsulfanyl-propyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-(3-phenylsulfanyl-propyl) ester(167963-62-4)
• EPA Substance Registry System: 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-(3-phenylsulfanyl-propyl) ester(167963-62-4)

Safety Data

• Hazardous Substances Data: 167963-62-4(Hazardous Substances Data)

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 193539-61-6 (Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester 
• 167963-70-4 3-(phenylthio)propyl acetoacetate 
• 108-98-5 thiophenol 
• 88593-98-0 (3'-Bromo-1'-propyl)-3-oxobutanoate 

Relevant articles and documents

Mild and facile cleavage of 2-cyanoethyl ester using sodium sulfide or tetrabutylammonium fluoride. Synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetrical 1,4-dihydropyridine dicarboxylates

Several 3-(2-cyanoethyl)-1,4-dihydropyridine carboxylates (16) were prepared in moderate to good yields by means of the Hantzsch reaction. Treatment of these carboxylates with a weak base such as sodium sulfide or tetrabutylammonium fluoride at room temperature afforded smoothly the corresponding 1,4-dihydropyridine monocarboxylic acids (18) in good yields. The monocarboxylic acids 18n and 18o were esterified with 2-nitrooxypropanol or N-(2-hydroxyethyl)nicotinamide p-toluenesulfonic acid salt to afford the selective coronary vasodilators CD-349 (5) and CD-832 (6), respectively.