168015-04-1

Basic information

• Product Name: 2-bromo-6-(hydroxymethyl)-3-pyridinol
• Synonyms: 2-bromo-6-(hydroxymethyl)-3-pyridinol;2-bromo-6-(hydroxymethyl)pyridin-3-ol(WX191869)
• CAS NO: 168015-04-1
• Molecular Formula: C6H6BrNO2
• Molecular Weight: 204.02134
• Mol File: 168015-04-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127-128°
• Boiling Point: 424.0±40.0 °C(Predicted)
• Appearance: /
• Density: 1.836±0.06 g/cm3(Predicted)
• PKA: 4.24±0.10(Predicted)
• CAS DataBase Reference: 2-bromo-6-(hydroxymethyl)-3-pyridinol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-6-(hydroxymethyl)-3-pyridinol(168015-04-1)
• EPA Substance Registry System: 2-bromo-6-(hydroxymethyl)-3-pyridinol(168015-04-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 168015-04-1(Hazardous Substances Data)

Upstream product

• 6602-32-0 2-bromo-pyridin-3-ol 
• 50-00-0 formaldehyd 
• 24207-04-3 2-bromo-3-hydroxy-6-methylpyridine 1-oxide 
• 23003-35-2 2-bromo-3-hydroxy-6-methylpyridine 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 89098-98-6 6-(acetoxymethyl)-2-bromopyridin-3-yl acetate 

Downstream Products

• 905562-91-6 (6-bromo-5-methoxypyridin-2-yl)methanol 
• 1610372-95-6 4-(3-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-6-formylpyridin-2-yl)-N,N,3-trimethylbenzamide 
• 1610372-96-7 4-(3-(2-bromoethoxy)-6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)pyridin-2-yl)-N,N,3-trimethylbenzamide 
• 1610372-89-8 1-(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)ethyl)pyrrolidine 1-oxide 
• 1610372-81-0 5,7-dimethoxy-2-(6-(4-(methylsulfinyl)phenyl)-5-(2-(pyrrolidin-1-yl)ethoxy)pyridin-2-yl)quinazolin-4(3H)-one 
• 1610373-93-7 2-[5-(2-methanesulfonyloxyethoxy)-6-(4-methanesulfinylphenyl)pyridin-2-yl]-5,7-dimethoxy-3H-quinazolin-4-one 
• 1610372-79-6 tert-Butyl (2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate 
• 1610373-88-0 tert-butyl(2-((6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylthio)phenyl)pyridin-3-yl)oxy)ethyl)(isopropyl)carbamate 
• 1610373-27-7 2-(5-(2-bromoethoxy)-6-(3-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610373-23-3 6-(4-acetylphenyl)-5-(2-((tert-butyldimethylsilyl)oxy)ethoxy)picolinaldehyde 
• 1610373-22-2 2-(5-(2-bromoethoxy)-6-(4-(methylsulfonyl)phenyl)pyridin-2-yl)-5,7-dimethoxyquinazolin-4(3H)-one 
• 1610372-29-6 4-(6-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-3-(2-(isopropylamino)ethoxy)pyridin-2-yl)-N,N,3-trimethylbenzamide 
• 1610372-92-3 2-(5-(2-(Isopropylamino)ethoxy)-6-(4-(methylsulfinyl)phenyl)pyridin-2-yl)-7-methoxyquinazolin-4(3H)-one 
• 1610373-99-3 2-((6-(7-methoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2-(4-(methylsulfinyl)phenyl)pyridin-3-yl)oxy)ethyl methanesulfonate 

Relevant articles and documents

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

INHIBITORS OF HIF AND ANGIOGENESIS

Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for example stroke and ischemic heart disease, and non-cancerous angiogenic diseases are provided.

1-(PIPERIDIN-4-YL)-1H-INDOLE DERIVATIVE

The present invention provides a compound represented by the formula (1) or a pharmacologically acceptable salt thereof, or a hydrate thereof (provided that a compound in which all of R4a, R4b, and R4c are hydrogen atoms is excluded.): [wherein R1 represents a hydrogen atom, R2 represents a hydrogen atom, R3 represents the formula: wherein R4a, R4b, and R4c are the same as or different from each other and each represents a hydrogen atom, a C1-6 alkyl group or a C1-6 alkoxy group, etc.]