16807-11-7 Usage
Chemical Properties
White to yellow powder or crystals.
Uses
1-Bromo-9H-carbazole is a useful research chemical, mainly used as a pharmaceutical intermediate and an intermediate in organic synthesis.
Preparation
A 1-Bromo-9H-carbazole is synthesized as follows：Under noble gas protection, by 3,6- bis- Tert-butyl carbazole is dissolved in 1,2- dichloroethanes, adds hydrobromic acid, controlling reaction temperature to be slowly added dropwise hydrogen peroxide, dropping is completely Overnight, reactant liquor is washed, and separates organic layer for natural temperature reaction, is dried, and adds methyl alcohol dispersion, obtains the tertiary fourth of bromo- 3, the 6- of 1- bis- Base carbazole；Then 1- bromo- 3,6- di-t-butyl carbazole and isopropanol solvent are added in reaction bulb, controlling reaction temperature slowly adds Enter alchlor reaction, add water after terminating terminating reaction, through extraction, organic layer sodium hydrate aqueous solution is washed, and is dried overnight, concentrate Obtain crude product, methylene chloride-methanol mixed solvent is recrystallized to give product 1-Bromo-9H-carbazole.Production method of 1-bromocarbazole
Check Digit Verification of cas no
The CAS Registry Mumber 16807-11-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,8,0 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 16807-11:
(7*1)+(6*6)+(5*8)+(4*0)+(3*7)+(2*1)+(1*1)=107
107 % 10 = 7
So 16807-11-7 is a valid CAS Registry Number.
16807-11-7Relevant articles and documents
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Drake,N.L. et al.
, p. 1026 - 1030 (1962)
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Halogenated method of aromatic compound
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Paragraph 0091-0094; 0186-0188; 0195-0197, (2021/11/10)
The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.
1-bromo carbazole preparation method
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Paragraph 0057; 0058; 0063; 0064; 0068; 0069; 0073; 0074, (2017/11/29)
The invention discloses a 1-bromo carbazole preparation method, and belongs to the field of organic chemical synthesis. The preparation method specifically comprises: carrying out an Ullmann coupling reaction on raw materials such as o-bromoaniline and o-
