16814-08-7

Basic information

• Product Name: Phosphonic acid, (aminophenylmethyl)-, diethyl ester
• CAS NO: 16814-08-7
• Molecular Formula: C11H18NO3P
• Molecular Weight: 243.243
• Mol File: 16814-08-7.mol
• Article Data: 57

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (aminophenylmethyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (aminophenylmethyl)-, diethyl ester(16814-08-7)
• EPA Substance Registry System: Phosphonic acid, (aminophenylmethyl)-, diethyl ester(16814-08-7)

Safety Data

• Hazardous Substances Data: 16814-08-7(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 762-04-9 phosphonic acid diethyl ester 
• 121-44-8 triethylamine 
• 92-29-5 hydrobenzamide 
• 18108-19-5 Fluorsulfonylaminophenylmethanphosphonsaeurediethylester 
• 63207-61-4 (1-Phenyl-cyclopentyl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 63207-62-5 [Phenyl-(1-phenyl-cyclopentylamino)-methyl]-phosphonic acid diethyl ester; hydrochloride 
• 38428-05-6 diethyl ether of α-(N-benzyloxycarbonyl)aminobenzylphosphonic acid 
• 67764-57-2 diethyl 1-diphenylphosphinamino-1-phenylmethanephosphonate 
• 74732-28-8 (1-Isocyanato-1-phenyl)methylphosphonate de diethyle 
• 77526-40-0 diethyl ((2,2-dimethylhydrazono)(phenyl)methyl)phosphonate 
• 77526-41-1 [Phenyl-(phenyl-hydrazono)-methyl]-phosphonic acid diethyl ester 
• 100-47-0 benzonitrile 
• 64244-30-0 diethyl N-benzylidene-1-amino-1-phenylmethylphosphonate 

Downstream Products

• 43077-51-6 N-<α-(diethoxyphosphinyl)benzyl>-N'-phenylurea 
• 84454-05-7 diethyl (4-methylphenylsulfonamido)(phenyl)methylphosphonate 
• 146304-07-6 [(2-tert-Butoxycarbonylamino-acetylamino)-phenyl-methyl]-phosphonic acid diethyl ester 
• 146304-11-2 [(2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-phenyl-methyl]-phosphonic acid diethyl ester 
• 114518-73-9 diethyl benzimidoyl>phosphonate 
• 146304-21-4 C₂₉H₃₈N₂O₈P₂ 
• 18108-22-0 1-amino-1-phenylmethylphosphonic acid 
• 86052-40-6 ({[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-amino}-phenyl-methyl)-phosphonic acid diethyl ester 
• 38428-13-6 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester 
• 129416-31-5 diethyl acetimidoyl>phosphonate 
• 38428-05-6 diethyl ether of α-(N-benzyloxycarbonyl)aminobenzylphosphonic acid 

Relevant articles and documents

1-Aminoalkanephosphonates. Part II. A facile conversion of 1-aminoalkanephosphonic acids into O,O-diethyl 1-aminoalkanephosphonates

1-(N-Trifluoroacetylamino)alkanephosphonate O,O-diethyl esters 2C, obtained from parent 1-aminoalkanephosphonic acids 1, have been selectively deprotected on the amino function affording O,O-diethyl 1-aminoalkanephosphonates 3. Protonation constants of all amino esters 3 synthesized have been determined by potentiometric titration.

Carbon Dioxide-Mediated C(sp2)-H Arylation of Primary and Secondary Benzylamines

C-C bond formation by transition metal-catalyzed C-H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of ortho-arylbenzylamines, however, effective ortho-C-C bond formation of free primary and secondary benzylamines using PdII remains an outstanding challenge. Presented herein is a new strategy for constructing ortho-arylated primary and secondary benzylamines mediated by carbon dioxide (CO2). The use of CO2 with Pd is critical to allowing this transformation to proceed under relatively mild conditions, and mechanistic studies indicate that it (CO2) is directly involved in the rate-determining step. Furthermore, the milder temperatures furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, an interesting chelate effect is shown to facilitate selective monoarylation.

Synthesis and Biological Evaluation of (+)-Usnic Acid Derivatives as Potential Anti- Toxoplasma gondii Agents

Six series of (+)-usnic acid derivatives were synthesized. The IC50 values of these compounds were determined in T. gondii infected HeLa cells (μM) and in HeLa cells (μM), and their selectivity indexes (SI) were calculated. In vitro, most of th