168266-51-1Relevant articles and documents
Piperidine derivatives
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, (2008/06/13)
The present invention relates to piperidine derivatives of formula (I) STR1 wherein R 1 is a C 1-4 alkoxy group; R 2 is STR2 R 3 is a hydrogen or halogen atom; R 4 and R 5 may each independently represent a hydrogen or halogen atom, or aC 1-4 alkyl, C 1-4 alkoxy or trifluoromethyl group;R 6 is a hydrogen atom, a C 1-4 alkyl, (CH 2) m cyclopropyl, --S(O) n C 1-4 alkyl, phenyl,NR 7 R 8, CH 2 C(O)CF 3 or trifluoromethyl group;R 7 and R 8 may each independently represent a hydrogen atom, or a C 1-4 alkyl or acyl group;x represents zero or 1;n represents zero, 1 or 2;m represents zero or 1;and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.