1683-85-8

Basic information

• Product Name: 2-Pyrimidinamine, 5-fluoro- (9CI)
• Synonyms: 2-Pyrimidinamine, 5-fluoro- (9CI);2-AMINO-5-FLUOROPYRIMIDINE;5-fluoropyriMidin-2-aMine;5-Fluoro-2-pyrimidinamine;2-PyriMidinaMine,5-fluoro-;5-Fluoropyrimidin-2-amine, 2-Amino-5-fluoro-1,3-diazine
• CAS NO: 1683-85-8
• Molecular Formula: C4H4FN3
• Molecular Weight: 113.0930632
• Product Categories: PYRIMIDINE;Fluorine series
• Mol File: 1683-85-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 192-193℃
• Boiling Point: 280℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.372
• Refractive Index: 1.56
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.13±0.10(Predicted)
• CAS DataBase Reference: 2-Pyrimidinamine, 5-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 5-fluoro- (9CI)(1683-85-8)
• EPA Substance Registry System: 2-Pyrimidinamine, 5-fluoro- (9CI)(1683-85-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 1683-85-8(Hazardous Substances Data)

Usage

General Description

2-Pyrimidinamine, 5-fluoro- (9CI) is a chemical compound with the molecular formula C4H3FN4. It is a derivative of pyrimidinamine, a heterocyclic compound which contains a pyrimidine ring. The presence of the fluorine atom in the 5-position of the pyrimidine ring distinguishes this compound from other pyrimidines. This chemical may have potential applications in various fields including pharmaceuticals, agrochemicals, and materials science due to its unique structure and properties. Further research and development may reveal its specific uses and potential benefits in these industries.

InChI:InChI=1/C4H4FN3/c5-3-1-7-4(6)8-2-3/h1-2H,(H2,6,7,8)

Upstream product

• 62802-42-0 2-chloro-5-fluoropyrimidine 
• 128229-03-8 (Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide 
• 50-01-1 guanidine hydrochloride 
• 109-89-7 diethylamine 

Downstream Products

• 1354819-16-1 5-chloro-2,4-difluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 
• 1354819-21-8 N-(2,4-dimethoxybenzyl)-5-fluoropyrimidin-2-amine 

Relevant articles and documents

Compounds for treating spinal muscular atrophy

Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity

Reactions of 1-Substituted-polyfluoro-1-propenyl p-Toluenesulfonates with Bifunctional Nitrogen Nucleophiles. A New Expedient Access to Monofluorinated Nitrogen Heterocycles

1-Substituted-2,3,3-trifluoro-1-propenyl p-toluenesulfonates, readily available by the alkylation or arylation of 2,3,3-trifluoro-1-tosyloxy-1-propenyllithium or -zinc reagent, reacted smoothly with amidine or hydrazine derivatives at 70 deg C for 1h to give the corresponding 5-fluoropyrimidine or 4-fluoropyrazole compounds, respectively, in moderate to excellent yields.